In 2003, I completed my Masters in Physiology from the University of Calcutta, India. In 2004, I joined Dr. Sangeeta Bhaskar’s laboratory at the National Institute of Immunology, India and worked as a Research Fellow until 2011. I obtained my PhD in 2012 in Biotechnology from Jamia Hamdard, India. Currently I am doing my postdoctoral research in Dr. Chris Benedict’s laboratory at LJI since 2012.
My research is primarily focused on understanding the role of CD4 T cell responses in controlling persistent viral infection, and we use mouse cytomegalovirus (MCMV) as a model system. Our lab identified the first MCMV epitope-specific CD4 T cells, and showed that a unique, ‘late-rising’ response directed against an epitope derived from the viral M09 protein (M09133-147) shows very delayed expansion during ‘late persistence’. Using a variety of molecular and cellular techniques, I am investigating whether these ‘late-risers’ play a unique role in resolving viral persistence during natural infection and in a vaccine setting. Another focus has been to investigate whether late-rising CD4 T cells contribute to vascular complications that are associated with CMV infection, perhaps due to their unique chemokine responsiveness.
Strategic vaccination to combat persistent infections.