Bioinformatics Postdoc for Systems Vaccinology of B. Pertussis
The Peters lab at the La Jolla Institute for Immunology (LJI) is looking for a bioinformatician to join our recently funded efforts to profile the immune system response in different types of Pertussis vaccinations on how they relate to the recent resurgence of whooping cough.
Candidates with outstanding skills in the following areas are encouraged to apply for this position:
-Systems level analysis techniques (Dimensionality reduction, network analysis, machine learning)
-Experimental data analysis (RNA-Seq, flow/mass cytometry, single cell analysis)
Experience in immunology and vaccinology is a plus but not required. The position is expected to be filled by a candidate holding a PhD degree looking for advanced training positions, and will typically be for a period of 2-5 years.
How to apply: Interested candidates must include a cover letter, CV, and list of three references. Applications without a cover letter included will not be reviewed. Please apply here.
Background: In the mid-1990s, concerns over vaccine-related side effects prompted the widespread replacement of the whole-cell Pertussis (wP) vaccine in favor of a safer acellular Pertussis (aP) vaccine, and recent years witnessed a worldwide reemergence of Pertussis (whooping cough) despite widespread vaccination. Our approach is to compare individuals born before 1995 and vaccinated in infancy with wP, with individuals born in 1996 or later and vaccinated with aP in infancy, thus directly studying the population and age group in which the increased disease incidence is noted. The goal of this proposal is the identification of the mechanisms and correlates of long-lasting vaccine-induced immunity associated with Pertussis vaccination and more generally defining the mechanisms of durable vaccine efficacy.