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Next Generation Sequencing Core Manager

Job Summary

The Next Generation Sequencing (NGS) Core Facility at LJI is looking for an experienced full-time Core Manager. The successful candidate will be the Institute’s point of contact for our researchers’ sequencing-based questions. They will oversee our Next-Gen sequencing technicians, optimizing the high-throughput workflow for RNA and DNA sequencing library preparations, and will maintain a cutting-edge array of sequencers (including Illumina’s Novaseq 6000). In addition, the manager will continue to foster opportunities for the Core’s future, and will update our tools and protocols as new technologies arise. Additional responsibilities include working with a core team of technicians in the operation and maintenance of equipment, including integrated robotics platforms. The Core Manager will oversee the operation of the facility and screens, directly supervise staff members, and interface with scientists who wish to set up Next-Gen sequencing to advise them on assay development. The Core Manager is responsible for all screening performed at the facility, and for ensuring that it happens in as efficient a manner as possible.

Essential Duties & Responsibilities
•Administrative leadership. Including the Implementation of effective and streamlined systems for client requests, pricing and charging, and inventory tracking. This will involve constant analysis of cost structures for all Core services offered, maintaining budget equilibrium. Business management interest/expertise is highly desired.
•Working knowledge of current state-of-the-art NextGen Sequencing equipment, and knowledge and use of software needed to troubleshoot robotic screening platforms.
•Desire to maintain strong, collaborative relationships with other LJI Cores, PI’s, and Lab members. An ideal candidate will have strong interpersonal skills.
•Provide in-person, engaged consultation with researchers based on conceptual expertise of NGS Sequencing and its relationship to RNA and DNA seq methods. Competencies in bioinformatics tools is a critical advantage to working with experts in immunology but not necessarily informatics.
•Drive to optimize and maintain RNA and DNA sequencing protocols that improve efficiency, cost and reproducibility.
•Providing desktop support for computers used to control laboratory automation and instruments, and working with Institute IT staff to perform regular backups of instrument software programs and data.
•Making presentations and communicating effectively with a wide variety of audiences of differing skills levels, including lay audiences.

Leveling Requirements
•Experience in laboratory administrative tasks including management and oversight of external clientele and internal users, management of invoices and core budgets, inventory management, and scheduling
•Experience in QA/QC workflows.
•Five or more years of relevant work experience
•Specific experience in the use and integration of laboratory robots for HTS and in programming complex liquid handling platforms.
•Knowledge of high content screening methodologies. Experience with assays used in screening, ability to write and validate assay protocols and ability to advise users on assay development.
•Excellent communication skills, attention to detail, and ability to multi-task.
•Must be willing to foster and maintain collaborative relationships within the Institute.
•Must be aware of and enthusiastic about incorporating future technology into current and future scientific projects and endeavors.
•Advanced degree in bioinformatics, molecular/cell biology, or chemistry a plus

How to apply:
Interested applicants should upload their resume here. A cover letter is recommended but not required. All applications should be uploaded in a single file attachment.

About La Jolla Institute for Immunology

In 2018, LJI was ranked as one of the best places to work in San Diego by the San Diego business Journal, and in 2013, the Best Place to Work in Academia worldwide (The Scientist). The Institute hosts 24 world-renowned faculty and postdoctoral researchers hailing from 21 different countries. LJI is located in the Science Research Park on the campus of UC San Diego, with easy access to the San Diego life sciences community and all that the area has to offer.