Understanding the mechanisms of the immune response—how various immune cells function and respond to specific pathogens; how immune cells protect against some diseases and contribute to other chronic ones—is vitally important. We know that these processes are controlled by specialized genes in each immune cell type. Individual differences in genes can be critical, but we know relatively little about how these genetic variations affect the overall immune response by functioning in specific immune cells.
DICE is expected to significantly expand the knowledge that scientists have gained through genome-wide association studies. Genome-wide association studies have identified pieces of DNA that influence susceptibility to arthritis, diabetes or other conditions, but in most cases we do not know the function of those regions of our DNA. The studies funded by the new grant to LJI will help reveal these functions and spur the creation of the database.
Through the power of genomics, the database will offer researchers a view of the immune system in action by pinpointing genes that are active, or poised to be active, within each type of immune cell. With these maps in hand, researchers can focus directly on developing new vaccines and treatments for disease.