Type 1 Diabetes Center

Type 1 Diabetes Center

"The mission of our Center is based on two important realizations. The first is that it will be impossible to cure this disease without correcting the misdirected immune system that attacks the islets. The second realization is that tackling this disease will necessitate the cooperation of many, not only scientists from diverse disciplines such as the La Jolla Institute, but in particular, the cooperation between basic researchers and clinicians."


The mission of the Type 1 Diabetes (T1D) Center at the La Jolla Institute for Immunology is to accelerate the path to find a safe prevention and cure for type 1 diabetes. The Center strives to combine the in-house multidisciplinary expertise in immunology and development of immunotherapies with cutting edge approaches in beta cell regeneration and replacement and local clinical centers. Therefore, close ties with the Brehm Coalition, the Pediatric Diabetes Research Center (PDRC) of San Diego, and the Sanford Foundation have been established. These collaborations are united by their dedication to fighting type 1 diabetes and helping those who suffer from it, and ultimately, all who are touched by the disease.

Cure for Type 1 Diabetes

Day by day, Center Director Matthias von Herrath, M.D., and his lab are edging closer to a goal that has eluded the scientific community for nearly a century—a cure for type 1 diabetes. Von Herrath and his fellow researchers' development of a combination therapy is showing significant promise in type 1 diabetes when caught in the early stages. Work on this promising research continues, with clinical testing currently under way on each of the combination therapy components individually. If required government approvals are received, human clinical trials of the combination therapy are planned.


Catherine “Lynn” Hedrick, Ph.D.
Matthias von Herrath, M.D.

From The Lab

Dec 12, 2018 // Expertscape

LJI Professor named world’s leading Type 1 Diabetes expert

Mar 23, 2018 // Science Immunology

Bystander T cells can steal the show from "professional" regulatory cells in resolving inflammation

Nov 1, 2016

LJI scientists flip molecular switches to distinguish closely related immune cell populations

May 17, 2016 // Medical Daily

Germs may trigger killer T cells to attack insulin-producing beta cells, causing type 1 diabetes

May 16, 2016 // Science Daily

Do germs trigger type 1 diabetes?