One of the most effective tools in our arsenal against emerging viral threats is the rapid identification and deployment of therapeutics and vaccines. My research leverages structural biology to decipher the architecture and functional mechanisms of viral proteins. By characterizing the structures of viral surface glycoproteins in complex with antibodies, I aim to elucidate the fundamental mechanisms driving human humoral responses to viral infection, revealing vulnerabilities in these often heavily cloaked proteins.
Hastie Lab
Kathryn Hastie, Ph.D.
Research Assistant Professor, Director of Antibody Discovery
Center for Vaccine Innovation
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My lab is driven by a simple curiosity: how do viral glycoproteins subvert and hide from the human immune system to cause such devastating global effects? By mapping the antigenic landscapes of these heavily cloaked proteins, my lab transforms antibody-defined maps of viral vulnerability into precise, actionable blueprints for pandemic preparedness.
Featured Publications
Hastie KM, Yu X, Ana-Sosa-Batiz F, Zyla DS, Harkins SS, Hariharan C, Wasserman H, Zandonatti MA, Miller R, Maule E, Kim K, Valentine KM, Shresta S, Saphire EO
Oct 26, 2022
- Science Translational Medicine
Haoyang Li , Tierra Buck, Michelle Zandonatti, Jieyun Yin, Alex Moon-Walker, Jingru Fang, Anatoliy Kovalmegan L. Heinrich, Megan M. Rowland, Ruben Diaz Avalos, Sharon L. Schendel, Diptiben Parekh, Dawid Zyla, Adrian Enriquez, Stephanie Harkins, Brian Sullivan, Victoria Smith, Onyeka Chukwudozie, Reika Watanabe, James E. Robinson, Robert F. Garry, Luis M. Branco, Kathryn M. Hastie, Erica Ollmann Saphire
Hastie KM, Li H, Bedinger D, Schendel SL, Dennison SM, Li K, Rayaprolu V, Yu X, Mann C, Zandonatti M, Avalos Diaz R, Zyla D, Buck T, Hui S, Shaffer K, Hariharan C, Yin J, Olmedillas E, Enrqiuez A, Parekh D, Abraha M, Feeney E, Horn GQ, CoVIC-DB team1, Aldon Y, Ali H, Aracic S, Cobb RR, Federman RS, Fernandez JM, Glanville J, Green R, Grigoryan G, Lujan Hernandez AG, Ho DD, Huang KA, Ingraham J, Jiang W, Kellam P, Kim C, Kim M, Kim HM, Kong C, Krebs SJ, Lan F, Lang G, Lee S, Leung CL, Liu J, Lu Y, MacCamy A, McGuire AT, Palser AL, Rabitts TH, Tehrani ZR, Sajadi MM, Sanders RW, Sato AK, Schweizer L, Seo J, Shen B, Snitselaar JJ, Stamatatos L, Tan Y, Tomic MT, van Gils M, Youssef S, Yu J, Yuan TZ, Zhang Q, Peters B, Tomaras GD, Germann T, Saphire EO.
Hastie KM, Cross RW, Harkins SS, Zandonatti MA, Koval AP, Heinrich ML, Rowland MM, Robinson JE, Geisbert TW, Garry RF, Branco LM, Saphire EO
Jun 3, 2017
- Science
Hastie KM, Zandonatti MA, Kleinfelter LM, Heinrich ML, Rowland MM, Chandran K, Branco LM, Robinson JE, Garry RF, Saphire EO.
Acciani M, Zyla D, Niemeyer G, Harkins S, Parekh D, Pawlack E, LaCarbonara D, Niewiesk S, Porotto M, Hastie KM, Saphire EO
Lab Members
Kathryn Hastie, Ph.D.
Research Assistant Professor & Director, Antibody Discover
Research Projects
In my role as Director of Antibody Discovery, I developed a robust, high-throughput platform to isolate lead therapeutic and diagnostic antibodies within weeks of viral emergence or immunization. Key successes [...]
The New World Arenaviruses are highly pathogenic viruses spread by rodents ubiquitous in the Americas. No vaccines or therapeutics are yet approved. My lab is characterizing first-in-class antibodies that neutralize [...]
Awards & Honors
PEGS Young Scientist Keynote Speaker, in recognition of outstanding work in the field of protein science, 2019Spicer Young Investigator Award, for the most outstanding contribution to society from research performed at the SSRL national resource, 2017
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