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Matthias Von Herrath, M.D.
Professor
Center for Autoimmunity and Inflammation
"Type 1 diabetes is particularly tragic because it usually starts in childhood and its effects worsen with time. It can lead to organ damage, blindness and other terrible side effects. That's why I focus so heavily on this disease. I'm trained as a physician and I saw what it can do."

Overview

Dr. Matthias von Herrath is committed to clinical translation of immune-based interventions in autoimmune and metabolic diseases, the latter in particular being an exciting emerging field. His expertise and main strength is working at the interface of experimental research to interpret and refine early phase I/II clinical trials in order to optimize strategies for phase 3 trials and drug approval. This comprises translation from various animal models to human interventions, optimization of immunotherapies and their relative ranking, assessment of combination therapies, development of biomarkers as primary or secondary outcomes, induction of antigen specific tolerance in autoimmunity, regulatory cells and clinical T cell assays. In order to be better able to pursue his goal of clinical translation, Dr. von Herrath accepted the position of Vice President and Head of NovoNordisk’s diabetes R&D Center in Seattle in autumn of 2011. At NovoNordisk, he built the diabetes translational unit, which is based on less conventional and innovative design.

Understanding disease pathology remains very close to Dr. von Herrath’s heart and NovoNordisk enabled him to keep an appointment at La Jolla Institute, where he pursues NIH-funded research on the pathology of type 1 and 2 diabetes as part of the national pancreatic organ donor network (nPOD). This is a multinational collaborative effort where data are shared in real time and no intellectual property yet lots of new knowledge on the pathology of type 1 and 2 diabetes is being generated. It is a unique new collaborative paradigm for academic and also industry settings.

Featured publications

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Lab Members

GA
CB
MB
EC
TC
MV
NV
SZ

Research Projects

von Herrath
Characterization of HLA class I expression in autoantibody positive and type 1 diabetic donors

Team: Mehdi Benkahla and Somayeh Sabouri Type 1 diabetes (T1D) is an autoimmune disease characterized by increased blood glucose levels

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von Herrath
Characterization of in-situ IL17 expression in human pancreas

Team: Sakthi Rajendran, Estefania Quesada-Masachs and Mehdi Benkahla IL-17 is a pro-inflammatory cytokine important in shaping host immune responses against

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von Herrath
Characterization of specificity and phenotype of pancreatic CD8 T cells in human Type 1 Diabetes

Team: Christine Bender A better understanding of type 1 diabetes (T1D) is the first step to potentially developing new therapies

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von Herrath
Detailed in-situ characterization of cytokines, immune and endocrine cell in the human pancreas

Team: Sakthi Rajendran, Estefania Quesada-Masachs, Christine Bender Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction of

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von Herrath
Exploring toxic effects of T1D patient’s serum in pancreatic β cells

Team: Estefania Quesada-Masachs, Sakthi Rajendran Type 1 diabetes (T1D), an autoimmune disease that usually affects young people, is on the

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von Herrath
Expression of HLA class II in human pancreatic tissue sections

Team: Estefania Quesada-Masachs, Sakthi Rajendran Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing β cells are attacked

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From the lab

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Awards & Honors

  • 2007-2012 Scholar Award from the Juvenile Diabetes Foundation
  • 2008 American Diabetes Association–Lilly Outstanding Scientist Achievement Award
  • 2006 Grotzky Award from the Juvenile Diabetes Foundation International