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Jan 21, 2021 Sci Immunol

Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8+ T cells

Kusnadi A, Ramírez-Suástegui C, Fajardo V, Chee SJ, Meckiff BJ, Simon H, Pelosi E, Seumois G, Ay F, Vijayanand P, Ottensmeier CH

Mar 15, 2021 J Immunol

Functional analysis of immue signature genes in Th1* memory cells links ISOC1 and pyrimidine metabolism to IFN-g and IL-17 production

Kushnareva, Y., Mathews, I.T., Andreyev, A.Y., Altay, G., Lindestam Arlehamn, C.S., Pandurangan, V., Nilsson, R., Jain, M., Sette, A., Peters, B., and Sharma, S

Mar 15, 2021 Development

Sox2-Evf2 lncRNA-mediated mechanisms of chromosome topological control in developing forebrain. Development.

Cajigas I, Chakraborty A, Lynam M, Swyter KR, Bastidas M, Collens L, Luo H, Ay F, Kohtz JD.

Apr 1, 2021 Genome Res

Multi-cell type gene coexpression network analysis reveals coordinated interferon response and cross-cell type correlations in systemic lupus erythematosus

Panwar B, Schmiedel BJ, Liang S, White B, Rodriguez E, Kalunian K, McKnight AJ, Soloff R, Seumois G, Vijayanand P, Ay F.

Apr 27, 2021 Genome Res

Third-generation sequencing revises the molecular karyotype for Toxoplasma gondii and identifies emerging copy number variants in sexual recombinants.

Xia J, Venkat A, Bainbridge RE, Reese ML, Le Roch KG, Ay F, Boyle JP

Jun 24, 2021 Nat Immunol

Intratumoral follicular regulatory T cells curtail anti-PD-1 treatment efficacy

Eschweiler S, Clarke J, Ramírez-Suástegui C, Panwar B, Madrigal A, Chee SJ, Karydis I, Woo E, Alzetani A, Elsheikh S, Hanley CJ, Thomas GJ, Friedmann PS, Sanchez-Elsner T, Ay F, Ottensmeier CH, Vijayanand P

May 20, 2021 Bioinformatics

ExTraMapper: Exon- and Transcript-level mappings for orthologous gene pairs

Chakraborty A, Ay F, Davuluri RV

May 5, 2021 Research News

A new window into autoimmune diseases

LJI scientists uncover coordinated immune cell activity as a driver of systemic lupus erythematosus

Jan 1, 2021 Nat genet.

Promoter-interacting expression quantitative trait loci are enriched for functional genetic variants

Chandra V, Bhattacharyya S, Schmiedel BJ, Madrigal A, Gonzalez-Colin C, Fotsing S, Crinklaw A, Seumois G, Pejman M, Kronenberg M, Peters B, Ay F, Vijayanand P

Mar 23, 2021 Institute News

The Conrad Prebys Foundation grants more than $450,000 for studies into childhood cancer, cardiovascular disease

New funding will support high-risk, high-reward projects led by two early-career scientists

Jan 25, 2021 Research News

LJI asthma researcher Jermaine Khumalo receives AAI Intersect Fellowship

New fellowship will support data science and immunology cross-training in two pioneering LJI labs

Jul 1, 2020 SSRN

Single-Cell Transcriptomic Analysis of SARS-CoV-2 Reactive CD4 + T Cells

Meckiff BJ, Ramírez-Suástegui C, Fajardo V, Chee SJ, Kusnadi A, Simon H, Grifoni A, Pelosi E, Weiskopf D, Sette A, Ay F, Seumois G, Ottensmeier C, Vijayanand P.