New LJI research has major implications for controlling T cell activity
How a supposed "nuclear" receptor makes TCR signaling possible
Epithelial HVEM maintains intraepithelial T cell survival and contributes to host protection.
Origin story: How T cell heroes and villains are made
LJI Postdoctoral Fellow Greet Verstichel on how T cells learn their "fate"
Amazing mucosa
“The whole mucosal immune system is so fascinating. It has to operate in an environment of extremes.”
HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160.
Regulation of mucosal immunity by stromal cells and dendritic cells crosstalk in the gut
Genetic regulation by vitamin A is involved in multiple biological processes such as embryonic development, vision, and immunity. To exert
The Contribution of Central and/or Peripheral Tolerance in Celiac Disease
Celiac Disease (CD) is an autoimmune-like inflammatory disease induced by aberrant immune responses initiated by MHC class II restricted CD4
Mucosal CD4- CD8- T Cells
One large subgroup of specialized T cells is encompassed by the intraepithelial T cells which are located in the epithelium
Role of Pre-TCR Signaling in Central Tolerance and Autoimmunity?
Autoimmunity is a self-destructive disease condition mediated mainly by pathogenic selfreactive αβ T cell receptor (TCR) expressing T lymphocytes. Self-tolerance
Mechanisms Involved in The Generation of High Affinity Effector Memory T Cells
A hallmark of immune memory is that repeated infections are met with accelerated or/and enhanced protective immunity. Furthermore, unlike naive