Ivy Phung works to build better vaccines

Sep 18, 2023 Behind the Science

Ivy Phung works to build better vaccines

How a Ph.D. student found a place in the intense world of HIV vaccine research

Aug 22, 2023 Institute News

La Jolla Institute for Immunology appoints Shane Crotty, PhD, as Chief Scientific Officer

Dr. Crotty will lead LJI’s overall scientific strategy, as well as oversee research operations to support the success of the Institute’s scientific initiatives.

Apr 15, 2023 BioRxiv

Mll1 pioneers histone H3K4me3 deposition and promotes formation of CD8 + T stem cell memory

Getzler AJ, Frederick MA, Milner JJ, Venables T, Diao H, Toma C, Nagaraja SD, Albao DS, Bélanger S, Tsuda SM, Kim J, Crotty S, Goldrath AW, Pipkin ME

Apr 20, 2023 Cell Chem Biol

Structural basis for antibody-mediated neutralization of lymphocytic choriomeningitis virus

Moon-Walker A, Zhang Z, Zyla DS, Buck TK, Li H, Diaz Avalos R, Schendel SL, Hastie KM, Crotty S, Saphire EO

Apr 26, 2023 Annu Rev Immunol

T cell responses to SARS-CoV-2

Sette A, Sidney J, Crotty S

May 9, 2023 Immunity

DNA architectural protein CTCF facilitates subset-specific chromatin interactions to limit the formation of memory CD8+ T cells

Quon S, Yu B, Russ BE, Tsyganov K, Nguyen H, Toma C, Heeg M, Hocker JD, Milner JJ, Crotty S, Pipkin ME, Turner SJ, Goldrath AW

May 12, 2023 Sci Immunol

Transcriptional programming of CD4+ TRM differentiation in viral infection balances effector- and memory-associated gene expression

Nguyen QP, Takehara KK, Deng TZ, O'Shea S, Heeg M, Omilusik KD, Milner JJ, Quon S, Pipkin ME, Choi J, Crotty S, Goldrath AW

Jun 1, 2023 J Immunol

The chromatin Rregulator Mll1 supports T follicular helper cell differentiation by controlling expression of Bcl6, LEF-1, and TCF-1

Bélanger S, Haupt S, Faliti CE, Getzler A, Choi J, Diao H, Karunadharma PP, Bild NA, Pipkin ME, Crotty S

Jun 27, 2023 bioRxiv

Focusing antibody responses to the fusion peptide in rhesus macaques

Cottrell CA, Pratap PP, Cirelli KM, Carnathan DG, Enemuo CA, Antanasijevic A, Ozorowski G, Sewall LM, Gao H, Greene KM, Allen JD, Ngo JT, Choe Y, Nogal B, Silva M, Bhiman J, Pauthner M, Irvine DJ, Montefiori D, Crispin M, Burton DR, Silvestri G, Crotty S, Ward AB

Feb 1, 2023 Nature

Author Correction: Long-primed germinal centres with enduring affinity maturation and clonal migration

Lee JH, Sutton HJ, Cottrell CA, Phung I, Ozorowski G, Sewall LM, Nedellec R, Nakao C, Silva M, Richey ST, Torres JL, Lee WH, Georgeson E, Kubitz M, Hodges S, Mullen TM, Adachi Y, Cirelli KM, Kaur A, Allers C, Fahlberg M, Grasperge BF, Dufour JP, Schiro F, Aye PP, Kalyuzhniy O, Liguori A, Carnathan DG, Silvestri G, Shen X, Montefiori DC, Veazey RS, Ward AB, Hangartner L, Burton DR, Irvine DJ, Schief WR, Crotty S

Feb 21, 2023 Cell Rep Med

Dynamic activity in cis-regulatory elements of leukocytes identifies transcription factor activation and stratifies COVID-19 severity in ICU patients

Lam MTY, Duttke SH, Odish MF, Le HD, Hansen EA, Nguyen CT, Trescott S, Kim R, Deota S, Chang MW, Patel A, Hepokoski M, Alotaibi M, Rolfsen M, Perofsky K, Warden AS, Foley J, Ramirez SI, Dan JM, Abbott RK, Crotty S, Crotty Alexander LE, Malhotra A, Panda S, Benner CW, Coufal NG

Mar 31, 2023 Sci Immunol

The transcription factor Mef2d regulates B:T synapse-dependent GC-TFH differentiation and IL-21-mediated humoral immunity

Kim YJ, Oh J, Jung S, Kim CJ, Choi J, Jeon YK, Kim HJ, Kim JW, Suh CH, Lee Y, Im SH, Crotty S, Choi YS