Can your macrophages ‘smell’ infections?

Aug 9, 2022 Institute News

Can your macrophages ‘smell’ infections?

LA JOLLA, CA—La Jolla Institute for Immunology (LJI) Instructor Marco Orecchioni, Ph.D., has shown that olfactory receptors are important for

May 20, 2022 Research News

Haywire T cells attack protein in “bad” cholesterol

LA JOLLA, CA—Preventing atherosclerosis, the underlying cause of heart disease, means scientists need to understand how immune cells drive inflammation

Jan 7, 2021 Blood.

Kindlin-3 recruitment to the plasma membrane precedes high affinity beta2 integrin and neutrophil arrest from rolling.

Wen L, Marki A, Roy P, McArdle S, Sun H, Fan Z, Gingras AR, Ginsberg MH, Ley K.

Mar 21, 2021 Cardiovasc Res.

Classical monocyte transcriptomes reveal significant anti-inflammatory statin effect in women with chronic HIV.

Ehinger E, Ghosheh Y, Pramod AB, Lin J, Hanna DB, Mueller K, Durant CP, Baas L, Qi Q, Wang T, Buscher K, Anastos K, Lazar JM, Mack WJ, Tien PC, Cohen MH, Ofotokun I, Gange S, Heath SL, Hodis HN, Tracy RP, Landay AL, Kaplan RC, Ley K.

Aug 1, 2021 J Am Soc Nephrol.

Data-driven kidney transplant phenotyping as a histology-independent framework for biomarker discovery.

Buscher K, Heitplatz B, Van Marck V, Song J, Loismann S, Rixen R, Huchtmann B, Kurian S, Ehinger E, Wolf D, Ley K, Pavenstaedt H, Reuter S.

Jul 27, 2021 Cardiovasc Res.

Fortified tregs to fight atherosclerosis.

Ley K.

Nov 1, 2021 Mol Metab.

Myeloid cell-specific Irf5 deficiency stabilizes atherosclerotic plaques in Apoe(-/-) mice.

Leipner J, Dederichs TS, von Ehr A, Rauterberg S, Ehlert C, Merz J, Dufner B, Hoppe N, Krebs K, Heidt T, von Zur Muehlen C, Stachon P, Ley K, Wolf D, Zirlik A, Bode C, Hilgendorf I, Hardtner C.

Oct 26, 2021 mBio.

Endothelial heparan sulfate mediates hepatic neutrophil trafficking and injury during staphylococcus aureus sepsis.

Golden GJ, Toledo AG, Marki A, Sorrentino JT, Morris C, Riley RJ, Spliid C, Chen Q, Cornax I, Lewis NE, Varki N, Le D, Malmstrom J, Karlsson C, Ley K, Nizet V, Esko JD.

Dec 1, 2021 J Immunol.

Thymus-derived CD4+CD8+ cells reside in mediastinal adipose tissue and the aortic arch.

Winkels H, Ghosheh Y, Kobiyama K, Kiosses WB, Orecchioni M, Ehinger E, Suryawanshi V, Herrera-De La Mata S, Marchovecchio P, Riffelmacher T, Thiault N, Kronenberg M, Wolf D, Seumois G, Vijayanand P, Ley K.

Nov 22, 2021 Cardiovasc Res.

Heterogeneity of immune cells in human atherosclerosis revealed by scRNA-Seq.

Vallejo J, Cochain C, Zernecke A, Ley K.

Mar 1, 2021 Nat Immunol.

A CD22-Shp1 phosphatase axis controls integrin beta7 display and B cell function in mucosal immunity.

Ballet R, Brennan M, Brandl C, Feng N, Berri J, Cheng J, Ocon B, Alborzian Deh Sheikh A, Marki A, Bi Y, Abram CL, Lowell CA, Tsubata T, Greenberg HB, Macauley MS, Ley K, Nitschke L, Butcher EC.

Mar 1, 2021 J Exp Med.

Elongated neutrophil-derived structures are blood-borne microparticles formed by rolling neutrophils during sepsis.

Marki A, Buscher K, Lorenzini C, Meyer M, Saigusa R, Fan Z, Yeh YT, Hartmann N, Dan JM, Kiosses WB, Golden GJ, Ganesan R, Winkels H, Orecchioni M, McArdle S, Mikulski Z, Altman Y, Bui J, Kronenberg M, Chien S, Esko JD, Nizet V, Smalley D, Roth J, Ley K.