A Biotin Targeting Chimera (BioTAC) System to Map Small Molecule Interactomes in situ

Aug 22, 2023 bioRxiv

A Biotin Targeting Chimera (BioTAC) System to Map Small Molecule Interactomes in situ

Tao AJ, Jiang J, Gadbois GE, Goyal P, Boyle BT, Mumby EJ, Myers SA, English JG, Ferguson FM.

Sep 12, 2023 Immunity

A regulatory circuit controlled by extranuclear and nuclear retinoic acid receptor alpha determines t cell activation and function

Larange A, Takazawa I, Kakugawa K, Thiault N, Ngoi S, Olive ME, Iwaya H, Seguin L, Vicente-Suarez I, Becart S, Verstichel G, Balancio A, Altman A, Chang JT, Taniuchi I, Lillemeier B, Kronenberg M, Myers SA, Cheroutre H

Jun 19, 2023 Front Microbiol

Activation mechanism and activity of globupain, a thermostable C11 protease from the Arctic Mid-Ocean Ridge hydrothermal system

Røyseth V, Hurysz BM, Kaczorowska AK, Dorawa S, Fedøy AE, Arsın H, Serafim MSM, Myers SA, Werbowy O, Kaczorowski T, Stokke R, O'Donoghue AJ, Steen IH.

Feb 1, 2023 Leukemia

CALR-mutated cells are vulnerable to combined inhibition of the proteasome and the endoplasmic reticulum stress response

Jutzi JS, Marneth AE, Jiménez-Santos MJ, Hem J, Guerra-Moreno A, Rolles B, Bhatt S, Myers SA, Carr SA, Hong Y, Pozdnyakova O, van Galen P, Al-Shahrour F, Nam AS, Mullally A.

Jan 17, 2023 PNAS

OGT controls mammalian cell viability by regulating the proteasome/mTOR/ mitochondrial axis

Li X, Yue X, Sepulveda H, Burt RA, Scott DA, A Carr S, A Myers S, Rao A.

Feb 1, 2023 Leukemia

CALR-mutated cells are vulnerable to combined inhibition of the proteasome and the endoplasmic reticulum stress response

Jutzi JS, Marneth AE, Jiménez-Santos MJ, Hem J, Guerra-Moreno A, Rolles B, Bhatt S, Myers SA, Carr SA, Hong Y, Pozdnyakova O, van Galen P, Al-Shahrour F, Nam AS, Mullally A.

Jan 11, 2023 Research News

LJI scientists solve the mystery of why OGT enzyme is critical for cell survival

LA JOLLA, CA — Researchers at La Jolla Institute for Immunology (LJI) have at last uncovered how an enzyme called

Feb 1, 2022 Curr Opin Immunol.

Mechanisms encoding STAT functional diversity for context-specific inflammatory responses.

Myers SA, Gottschalk RA

Jan 1, 2022 Nat Immunol.

Identification of RIOK2 as a master regulator of human blood cell development.

Ghosh S, Raundhal M, Myers SA, Carr SA, Chen X, Petsko GA, Glimcher LH.

Jan 14, 2022 Blood

A Congenital Anemia Reveals Distinct Targeting Mechanisms for Master Transcription Factor GATA1.

Ludwig L, Lareau CA, Bao EL, Liu N, Utsugisawa T, Tseng AM, Myers SA, Verboon JM, Ulirsch JC, Luo W, Muus C, Fiorini C, Olive ME, Vockley CM, Munschauer M, Hunter A, Ogura H, Yamamoto T, Inada H, Nakagawa S, Ozono S, Subramanian V, Chiarle R, Glader B, Carr SA, Aryee MJ, Kundaje A, Orkin S, Regev A, McCavit T, Kanno H, Sankaran VG.

Mar 16, 2022 Nucleic Acids Res.

Retron reverse transcriptase termination and phage defense are dependent on host RNase H1.

Palka C, Fishman CB, Bhattarai-Kline S, Myers SA, Shipman SL.

Feb 1, 2022 Cur Opin Immunol.

Mechanisms encoding STAT functional diversity for context-specific inflammatory responses.

Myers SA, Gottschalk RA.