Aerosol Delivery of SARS-CoV-2 human monoclonal antibodies in macaques limits viral replication and lung pathology

Nov 3, 2023 Nat Commun

Aerosol Delivery of SARS-CoV-2 human monoclonal antibodies in macaques limits viral replication and lung pathology

Streblow DN, Hirsch AJ, Stanton JJ, Lewis AD, Colgin L, Hessell AJ, Kreklywich CN, Smith JL, Sutton WF, Chauvin D, Woo J, Bimber BN, LeBlanc CN, Acharya SN, O'Roak BJ, Sardar H, Sajadi MM, Tehrani ZR, Walter MR, Martinez-Sobrido L, Kobie JJ, Reader RJ, Olstad KJ, Hobbs TR, Saphire EO, Schendel SL, Carnahan RH, Knoch J, Branco LM, Crowe JE Jr, Van Rompay KKA, Lovalenti P, Vu Truong, Forthal DN, Haigwood NL

Oct 18, 2023 J Infect Dis

The Arenaviridae Family: Knowledge Gaps, Animal Models, Countermeasures, and Prototype Pathogens

Hastie KM, Melnik LI, Cross RW, Klitting RM, Andersen KG, Saphire EO, Garry RF

Dec 15, 2023 bioRxiv

Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformation

Olmedillas E, Rajamanickam RR, Avalos RD, Sosa FA, Zandonatti MA, Harkins SS, Shresta S, Hastie KM, Saphire EO

Nov 28, 2023 Cell Rep

The evolution and determinants of neutralization of potent head-binding antibodies against Ebola virus

Yu X, Hastie KM, Davis CW, Avalos RD, Williams D, Parekh D, Hui S, Mann C, Hariharan C, Takada A, Ahmed R, Saphire EO

Nov 17, 2023 bioRxiv

Identification of mouse CD4+ T cell epitopes in SARS-CoV-2 BA.1 spike and nucleocapsid for use in peptide:MHCII tetramers

Moreno LB, de Albuquerque JB, Neary JM, Nguyen T, Hastie KM, Landeras-Bueno S, Hariharan C, Nathan A, Getz MA, Gayton AC, Khatri A, Gaiha GD, Saphire EO, Luster AD, Moon JJ

Sep 7, 2023 Structure

The C-terminus of Sudan ebolavirus VP40 contains a functionally important CXnC motif, a target for redox modifications

Werner AD, Schauflinger M, Norris MJ, Klüver M, Trodler A, Herwig A, Brandstädter C, Dillenberger M, Klebe G, Heine A, Saphire EO, Becker K, Becker S

Sep 12, 2023 Nat Commun

A Lassa virus mRNA vaccine confers protection but does not require neutralizing antibody in a guinea pig model of infection

Ronk AJ, Lloyd NM, Zhang M, Atyeo C, Perrett HR, Mire CE, Hastie KM, Sanders RW, Brouwer PJM, Saphire EO, Ward AB, Ksiazek TG, Alvarez Moreno JC, Thaker HM, Alter G, Himansu S, Carfi A, Bukreyev A

Jun 24, 2023 bioRxiv

B cell and antibody targeting of transplant alloantigen epitopes is supported by both self and allo-recognition

Killian JT, King RG, Kizziah JL, Fucile CF, Diaz-Avalos R, Qiu S, Silva-Sanchez A, Mousseau BJ, Macon KJ, Callahan AR, Yang G, Hossain ME, Akther J, Houp JA, Rosenblum FD, Porrett PM, Ong SC, Kumar V, Saphire EO, Kearney JF, Randall TD, Rosenberg AF, Green TJ, Lund FE

Jul 22, 2023 Microsc Microanal

The in situ Structural Approach to Reveal the Filovirus Budding Mechanism

Watanabe R, Saphire EO

Jul 24, 2023 Nat Immunol

ChAdOx1 nCoV-19(AZD1222) vaccine-induced Fc receptor bindingtracks with differential susceptibilityto COVID-19

Kaplonek P, Cizmeci D, Kwatra G, Izu A, Lee JS, Bertera HL, Fischinger S, Mann C, Amanat F, Wang W, Koen AL, Fairlie L, Cutland CL, Ahmed K, Dheda K, Barnabas SL, Bhorat QE, Briner C, Krammer F, Saphire EO, Gilbert SC, Lambe T, Pollard AJ, Nunes M, Wuhrer M, Lauffenburger DA, Madhi SA, Alter G.

Nov 3, 2023 Institute News

Erica Ollmann Saphire wins 2023 Pantheon Award from California Life Sciences

LJI President and CEO celebrated among California’s leading life sciences innovators

Nov 2, 2023 Behind the Science

LJI joins national effort to prevent pandemics by harnessing the fascinating science of x-ray crystallography

With new funding, LJI scientists will help lay the groundwork for faster vaccine and therapeutic development