Human papillomavirus e5 suppresses immunity via inhibition of the immunoproteasome and sting pathway

May 30, 2023 Cell Rep

Human papillomavirus e5 suppresses immunity via inhibition of the immunoproteasome and sting pathway

Miyauchi S, Kim SS, Jones RN, Zhang L, Guram K, Sharma S, Schoenberger SP, Cohen EEW, Califano JA, Sharabi AB

May 24, 2022 BMJ Open

Demographic and clinical characteristics associated with variations in antibody response to bnt162b2 covid-19 vaccination among healthcare workers at an academic medical centre: A longitudinal cohort analysis.

Ebinger JE, Joung S, Liu Y, Wu M, Weber B, Claggett B, Botting PG, Sun N, Driver M, Kao YH, Khuu B, Wynter T, Nguyen TT, Alotaibi M, Prostko JC, Frias EC, Stewart JL, Goodridge HS, Chen P, Jordan SC, Jain M, Sharma S, Fert-Bober J, Van Eyk JE, Minissian MB, Arditi M, Melmed GY, Braun JG, McGovern DPB, Cheng S, Sobhani K.

Oct 17, 2022 Immune Matters

What it takes

LJI scientists shine a light into the depths of Alzheimer's disease

Feb 12, 2021 BMJ Open.

Seroprevalence of antibodies to SARS-CoV-2 in healthcare workers: a cross-sectional study.

Ebinger JE, Botwin GJ, Albert CM, Alotaibi M, Arditi M, Berg AH, Binek A, Botting P, Fert-Bober J, Figueiredo JC, Grein JD, Hasan W, Henglin M, Hussain SK, Jain M, Joung S, Karin M, Kim EH, Li D, Liu Y, Luong E, McGovern DPB, Merchant A, Merin N, Miles PB, Minissian M, Nguyen TT, Raedschelders K, Rashid MA, Riera CE, Riggs RV, Sharma S, Sternbach S, Sun N, Tourtellotte WG, Van Eyk JE, Sobhani K, Braun JG, Cheng S.

Mar 15, 2021 J Immunol.

Functional analysis of immune signature genes in Th1* memory cells links ISOC1 and pyrimidine metabolism to IFN-g and IL-17 production.

Kushnareva Y, Mathews IT, Andreyev AY, Altay G, Lindestam Arlehamn CS, Pandurangan V, Nilsson R, Jain M, Sette A, Peters B, Sharma S.

May 27, 2021 J Mass Spectrom.

Nontargeted mass spectrometry of dried blood spots for interrogation of the human circulating metabolome.

Ward C, Nallamshetty S, Watrous JD, Acres E, Long T, Mathews IT, Sharma S, Cheng S, Imam F, Jain M.

Apr 1, 2021 Nat Immunol.

The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING-IFN-β pathway.

Takahashi M, Lio CJ, Campeau A, Steger M, Ay F, Mann M, Gonzalez DJ, Jain M, Sharma S.

Aug 10, 2021 Immunity.

Smooth-talking T cells leave asthma breathless.

Romanov A, Sharma S.

Jul 6, 2021 Sci Rep.

Genome-wide CRISPR/Cas9 screening in human iPS derived cardiomyocytes uncovers novel mediators of doxorubicin cardiotoxicity.

Sapp V, Aguirre A, Mainkar G, Ding J, Adler E, Liao R, Sharma S, Jain M.

Jul 6, 2021 Genome Biol.

Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease.

Chu X, Jaeger M, Beumer J, Bakker OB, Aguirre-Gamboa R, Oosting M, Smeekens SP, Moorlag S, Mourits VP, Koeken V, de Bree C, Jansen T, Mathews IT, Dao K, Najhawan M, Watrous JD, Joosten I, Sharma S, Koenen H, Withoff S, Jonkers IH, Netea-Maier RT, Xavier RJ, Franke L, Xu CJ, Joosten LAB, Sanna S, Jain M, Kumar V, Clevers H, Wijmenga C, Netea MG, Li Y.

Oct 20, 2021 Immune Matters

Immune cells can detect cancer

Now we can see what they see — and help

Jun 11, 2021 Behind the Science

Sonia Sharma zeros in on metabolites

Cancer immunotherapies may have a better chance of working if scientists can reintroduce a missing metabolite