Influenza vaccine responses are highly heterogeneous, eliciting strong and durable immunity in some but little-to-no response in others. Our lab is bridging the gap between infant, adult, and elderly immunology to decode the rules underlying strong immunity at every stage of life. For infants receiving their first influenza vaccine, high levels of maternal antibodies can interfere with the vaccine response. Using a single blood draw from each mother, we can pinpoint the optimal time for vaccine administration, which generally ranges from 5-12 months of age. In adults, we are characterizing whether late-season vaccination can boost subsequent vaccine responses and beat the traditional annual vaccine schedule. In the elderly, we are using electronic health records to determine what traits act as a shield against infection in later life.
Beyond One-Size-Fits-All: Engineering the Future of Lifelong Immunity
About La Jolla Institute
The La Jolla Institute for Immunology is dedicated to understanding the intricacies and power of the immune system so that we may apply that knowledge to promote human health and prevent a wide range of diseases. Since its founding in 1988 as an independent, nonprofit research organization, the Institute has made numerous advances leading toward its goal: life without disease. Visit lji.org for more information.
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