Allergies result from your immune system overreacting to foreign substances, referred to as allergens. Reactions typically include coughing, sneezing, itchy eyes, a runny nose and a scratchy throat. T cells, a type of immune cell, play a central role in the human immune response to allergens. Detailed knowledge regarding specific allergen triggers that are recognized by T cells is currently limited.

The purpose of this study is to find out more about how these immune cells circulating in the blood and in the nose react to allergens in the air and in certain foods we eat. The information may be used to improve therapies for allergy sufferers. Individuals who have a history of allergy as well as non-allergic control subjects will be studied. Participants will be compensated for time and effort.

Eligibility Criteria:

• Generally healthy men and women, 18 years of age and older.
• History of allergy.

Coronavirus is a respiratory virus that commonly causes cold- and flu-like symptoms. It is present throughout the world, though outbreaks of new strains have occurred in the recent past. Since late 2019, a new strain has been identified as part of an outbreak in Hubei Province, China (“2019-novel coronavirus” or “SARS-CoV-2”).

As more and more people become infected with this new strain of the virus, it is important to understand as much as we can about how this strain of the virus affects the human immune system. We plan to look at the T and B cell immune response in patients with symptoms and history of COVID-19 disease as well as in healthy controls.

Eligibility Criteria (one or more):

• You are a generally healthy male or female, over 18 years of age.
• You have had a positive test for COVID-19.
• You have been vaccinated for COVID-19
• You have had a “breakthrough” infection of COVID-19 after being vaccinated

 An outbreak of Monkeypox (MPX) infections and associated disease was recently reported in Europe and North America. As of July 2022, several thousand cases have been confirmed in other countries, including over 3000 in USA. The 2022 global MPX outbreak has been recently declared a Public Health Emergency, is being monitored by health and regulatory agencies worldwide, and has received considerable attention in the general news. We plan to study the immune responses in subjects who have been infected with Monkeypox and have acquired T cell responses to the virus.

As more and more people become infected with this virus, it is important to understand as much as we can about how this  virus affects the human immune system. We plan to look at the T and B cell immune response in patients with symptoms and history of Monkeypox disease as well as those that have received a Monkeypox vaccine

Eligibility Criteria (one or more):

• You are a generally healthy male or female, over 18 years of age.
• You have had a positive test for Monkeypox
• Have received/will receive a Monkeypox vaccine

Mouse allergies are a common health problem around people who are frequently exposed to rodents, whether at home or work. Studies show that between 11-44% of all laboratory animal workers report work-related allergic symptoms. Symptoms can include sneezing, itchy and watery eyes, and skin rash. Up to 10% of workers may develop severe asthma from continuous mouse allergen exposure.

The purpose of this study is to find out more about how immune cells react with allergens from mice. Understanding these basic mechanisms of interaction will lead to better therapies for allergy sufferers and improve specific immunotherapy treatments (SIT). Participants will be compensated for time and effort..

Eligibility Criteria:

• Generally healthy men and women, 18 years of age and older.
• History of exposure or planned exposure to mice through work environments.

Parkinson’s Disease is a progressive neurological condition that affects movement and motor control. It is estimated that nearly one million people in the US are living with Parkinson’s disease, with more than 100,000 people diagnosed in southern California. Unfortunately, the cause of Parkinson’s disease is not entirely clear yet and many treatments only offer symptomatic relief.

The purpose of this study is to determine if there is a link between the immune system and Parkinson’s disease. Additionally, the study of DNA may show how genes influence the development of Parkinson’s disease. Understanding these basic mechanisms of interaction may help to lead to better treatments and diagnostic tools for Parkinson’s disease. Participants will be compensated for time and effort.

Eligibility Criteria:

• Generally healthy men and women, 50-70 years of age.
• Diagnosed by a physician with Parkinson’s disease -OR- older relatives, caregivers, or other persons (aged 50-70) interested in helping advance Parkinson’s research.

Untreated rabies infections are nearly 100% lethal and kill over 50,000 people every year. Although rabies vaccines and treatments are available, they are suboptimal. Rabies vaccines do not elicit a long-lasting immune response, and rabies treatments, which consist of a combination of human rabies immunoglobulin (pooled serum from vaccinees) administered at the site of infection and a series of rabies vaccines, are often prohibitively expensive.

In order to design a long-lasting rabies vaccine, we need to better understand how human rabies antibodies interact with rabies virus. This project aims to isolate antibodies and antibody producing cells from human blood in order to understand the human rabies immune response and to develop anti-rabies therapeutic antibodies.

Eligibility Criteria (one or more):

• You are a generally healthy male or female, over 18 years of age.
• You have had a rabies vaccine in the last 6-12 months

Vaccines function by promoting immune responses to infectious agents and thereby prevent illness associated with natural infection. An effective vaccine boosts your natural immune system (generating B and T memory cells), which in most cases provides life-long immunity to infection. The necessity to understand the function and interaction of these immune cell types is central to understanding how to improve vaccines and make them more effective.

The purpose of this study is to identify the characteristics of effective vaccine responses by studying the immune cells in individuals who receive vaccinations against a variety of infectious agents at various time points. Volunteers who have previous history of exposure to various infections may also be enrolled as controls. Participants will be compensated for time and effort.

Eligibility Criteria:

• Generally healthy men and women, 18 years of age and older.
• Medical record of vaccination and/or previously diagnosed infection.

The La Jolla Institute for Immunology’s in-house Normal Blood Donor Program (NBDP) is a valuable resource of human blood for use in various research projects. Often, healthy donors are needed for comparison purposes in many studies that focus on disease processes.

The purpose of the NBDP at La Jolla Institute is to provide researchers with a consistent supply of healthy control donors to compare to their disease models. Participants for the NBDP will be alerted when the opportunity to donated blood is available each week and given the option to sign-up for specific blood donations. Participants will be compensated for time and effort.

Eligibility Criteria:

• Generally healthy men and women, 18 years of age and older.
• No history of Autoimmune disease, cancer, HIV or hepatitis B or C.