Hogan Lab

Hogan Lab

"In the last few years, physics, chemistry, and engineering have given us incisive new tools that can be applied to biological and medical problems. The challenge is to deploy these tools creatively to increase our understanding of cell biology and to discover treatments for human disease." — Patrick Hogan, Ph.D. // Professor
Division of Signaling and Gene Expression


Patrick Hogan, Ph.D., studies cells at the nano level – seeking to understand how protein-protein interactions on the submicroscopic scale can have gargantuan impacts on human health and disease. “My laboratory is interested in the processes by which proteins interact with each other and with DNA to turn on genes in the nucleus. That’s the whole secret of how T cells work,” he said, referring to the body’s infection-fighting white blood cells. “The interactions we study are subtle but can be the key to human health and disease.” Dr. Hogan researches how calcium entry into T cells turns on the genes that are necessary to fight infections and cancers. “This flows from my earlier work in neurobiology,” he said, “where we tried to understand how pain sensory neurons are activated. That was my apprenticeship in how calcium and other ions enter cells, and how cells perceive and respond to signals.” His laboratory made a landmark discovery in 2006, when they studied a protein, ORAI1, that was mutated in two children with immune deficiency, making the children unusually susceptible to life-threatening infections. Dr. Hogan related the immune deficiency directly to calcium by showing that ORAI1 forms the pore of the calcium entry channel in T cells. “The hopeful lesson we take from these immunodeficient patients is that it may be possible to develop new therapies for transplant rejection and autoimmune disorders by targeting the calcium channel,” he said.

From The Lab

Dec 6, 2015

Matchmaker lets calcium flow

Jun 23, 2013 // San Diego Union Tribune

T cell trigger found

Jun 23, 2013

La Jolla Institute discovers new player critical to unleashing T cells against disease

Hogan Lab



Near-infarared photoactivatable control of Ca(2+) signaling and optogenetic immunomodulation

He L, Zhang Y, Ma G, Tan P, Li Z, Zang S, Wu X, Jing J, Fang S, Zhou L, Wang Y, Huang Y, Hogan PG, Han G, Zhou Y
Proceedings of the National Academy of Sciences of the United States of America

TMEM110 regulates the maintenance and remodeling of mammalian ER-plasma membrane junctions competent for STIM-ORAI signaling

Quintana A, Rajanikanth V, Farber-Katz S, Gudlur A, Zhang C, Jing J, Zhou Y, Rao A, Hogan PG
Cell Calcium

The STIM1-ORAI1 microdomain

Hogan PG
Nature Cell Biology

Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca(2+) influx

Jing J, He L, Sun A, Quintana A, Ding Y, Ma G, Tan P, Liang X, Zheng X, Chen L, Shi X, Zhang SL, Zhong L, Huang Y, Dong…
Journal of General Physiology

Sphingomyelin, ORAI1 channels, and cellular Ca2+ signaling

Hogan PG
Biochemical and Biophysical Research Communications

Store-operated calcium entry: mechanisms and modulation

Hogan PG, Rao A
Nature Communications

STIM1 triggers a gating rearrangement at the extracellular mouth of the ORAI1 channel

Gudlur A, Quintana A, Zhou Y, Hirve N, Mahapatra S, Hogan PG
Journal of Medicinal Chemistry

Structure-based optimization of a peptidyl inhibitor against calcineurin-nuclear factor of activated T cell (NFAT) interaction

Qian Z, Dougherty PG, Liu T, Oottikkal S, Hogan PG, Hadad CM, Pei D
Proceedings of the National Academy of Sciences of the United States of America

ORAI1 calcium channel orchestrates skin homeostasis

Vandenberghe M, Raphaël M. Lehen'ki V, Gordienko D, Hastie R, Oddos T, Rao A, Hogan PG, Skyrma R, Prevarskaya N
Nature Structural & Molecular Biology

Initial activation of STIM1, the regulator of store-operated calcium entry

Zhou Y, Srinivasan P. Razavi S, Seymour S, Meraner P, Gudiur A. Stathopulos PB, Ikura M, Rao A, Hogan PG

An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry

Sharma S, Quintana A, Findlay GM, Mettlen M, Baust B, Jain M, Nilsson R, Rao A, Hogan PG

Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX

Ko M, Bandukwala HS, Chavez L, Aijö T, Pastor WA, Segal MF, Li H, Koh KP, Lähdesmäki H, Hogan PG, Aravind L, Rao A
Cell Research

Insights into CRAC channel gating and ion permeation

Hogan PG
Nature Structural & Molecular Biology

Balanced interactions of calcineurin with AKAP79 regulate Ca2+-calcineurin-NFAT signaling

Li H, Pink MD, Murphy JG, Stein A, Dell'Acqua ML, Hogan PG
Proceedings of the National Academy of Sciences of the United States of America

Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex

Sharma S, Findlay GM, Bandukawala HS, Oberdoerffer S, Baust B, Li Z, Schmidt V, Hogan PG, Sacks DB, Rao A
Trends in Cell Biology

Interaction of calcineurin with substrates and targeting proteins

Li H, Rao A, Hogan PG
Current Topics in Membranes

STIM-ORAI interactions that control the CRAC channel

Gudlur A, Zhou Y, Hogan PG

Principal Investigator


Patrick Hogan, Ph.D.


Dr. Hogan, who will join the Institute in early 2010, began his professional career in the Department of Neurobiology at Harvard Medical School, where he headed a research laboratory and taught neurobiology. In 1996, he moved his laboratory to the Harvard-affiliated Immune Disease Institute, and continued to teach at Harvard College and Harvard Medical School.

Dr. Hogan is internationally recognized for his work on the calcineurin-NFAT pathway, which regulates gene transcription in many cell types, and for his work on cellular calcium signaling. He holds baccalaureate and Ph.D. degrees from Harvard.

Lab Members

Lucy Chammas

Visiting Scientist

Bipan Kumar Deb

Visiting Scientist

Aparna Gudlur

Postdoctoral Fellow

Nupura Hirve

Research Technician III

Zachary Katz

Visiting Scientist

Giuliana Mognol

Postdoctoral Fellow

Jigar Patel


fan Pu


Soheila Vaezeslami

Visiting Scientist

Shenghui Xue

Postdoctoral Fellow

Ana Eliza Zeraik

Postdoctoral Fellow

Alice Zhang

Postdoctoral Fellow

Hogan Lab

Research Projects