Sette Lab
Alessandro Sette, Dr.Biol.Sci., defines in chemical terms the specific structures (epitopes) that the immune system recognizes and uses this knowledge to measure and understand immune responses.
Disease Tuberculosis
How T cells combat tuberculosis
By tracking T cell activity, researchers uncover promising tuberculosis vaccine and drug targets
LJI Professor Alessandro Sette elected to the American Academy of Microbiology
Sette has led investigations into the T cell response to SARS-CoV-2, tuberculosis, and more
Tuberculosis
The aim of this work, in collaboration with Dr. Bjoern Peters, is to identify and characterize T cell epitopes from Mycobacterium tuberculosis in vaccination and active infection (NIH/NIAID, 75N93019C00067). We are also interested in defining human immune signatures of different…
Once upon a BCG vaccine
To fight tuberculosis, LJI scientists uncover the key immune cells in play after BCG vaccination
New vaccine ingredient shows promise
Most vaccines include particles called adjuvants. But not all adjuvants are created equal.
Tuberculosis
Investigation of human immune signatures of latent MTB infection, active disease and BCG vaccination. (NIH/NIAID, U19 AI118626) Proteome-wide characterization of T cell epitopes from Mycobacterium tuberculosis in vaccination and active infection. (NIH/NIAID, 75N93019C00067) Goal: To define MTB-derived T cell epitopes…
Tuberculosis
T cell responses to Mycobacterium tuberculosis infection and vaccination: Following completion of a massive epitope discovery effort (also supported by an NIH contract), current work on TB includes identifying T cell signatures and immune responses elicited by non-tuberculous mycobacteria, which…
No cell is an island
LJI team finds that ‘doublet’ immune cells are much more common—and more important in disease—than previously thought