Tuberculosis

Investigation of human immune signatures of latent MTB infection, active disease and BCG vaccination. (NIH/NIAID, U19 AI118626)

Proteome-wide characterization of T cell epitopes from Mycobacterium tuberculosis in vaccination and active infection. (NIH/NIAID, 75N93019C00067)

Goal: To define MTB-derived T cell epitopes associated with vaccination and active TB infection, and submit them to the IEDB.

About La Jolla Institute

The La Jolla Institute for Immunology is dedicated to understanding the intricacies and power of the immune system so that we may apply that knowledge to promote human health and prevent a wide range of diseases. Since its founding in 1988 as an independent, nonprofit research organization, the Institute has made numerous advances leading toward its goal: life without disease. Visit lji.org for more information.

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As Chikungunya spreads into new regions, LJI scientists share a first look at how human T cells target the virus. Their findings may shed light on how viruses can trigger chronic disease.
“We found a missing puzzle piece that represents one possible reason why immunization efforts against CMV have been unsuccessful.”