Sette Lab

Alessandro Sette, Dr.Biol.Sci., defines in chemical terms the specific structures (epitopes) that the immune system recognizes and uses this knowledge to measure and understand immune responses.
Research to identify mechanisms and correlates of long-lasting vaccine-induced immunity to whooping cough. The lab aims to define transcriptional responses to vaccine boost from donors originally primed with aP vs. wP and identify cell types associated with differential responses, as…
Immunological Basis of Differences in Protection Between Pertussis Vaccines: The recent increase in cases of whooping cough among teenagers in the US suggests that the protection conferred by the acellular Bordetella pertussis vaccine (aP) that became standard in the mid…