Research to identify mechanisms and correlates of long-lasting vaccine-induced immunity to whooping cough. The lab aims to define transcriptional responses to vaccine boost from donors originally primed with aP vs. wP and identify cell types associated with differential responses, as well as characterize the differences in memory T cell responses in aP vs. wP donors and characterize the molecular mechanisms of differences in APC-priming of T cells in aP- vs. wP-vaccinated donors.
NIH/NIAID (U01AI141995)