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Patrick Hogan, Ph.D.
Professor
Center for Autoimmunity and Inflammation, Center for Cancer Immunotherapy
"In the last few years, physics, chemistry, and engineering have given us incisive new tools that can be applied to biological and medical problems. The challenge is to deploy these tools creatively to increase our understanding of cell biology and to discover treatments for human disease."

Overview

Patrick Hogan, Ph.D., studies cells at the nano level – seeking to understand how protein-protein interactions on the submicroscopic scale can have gargantuan impacts on human health and disease. “My laboratory is interested in the processes by which proteins interact with each other and with DNA to turn on genes in the nucleus. That’s the whole secret of how T cells work,” he said, referring to the body’s infection-fighting white blood cells. “The interactions we study are subtle but can be the key to human health and disease.” Dr. Hogan researches how calcium entry into T cells turns on the genes that are necessary to fight infections and cancers. “This flows from my earlier work in neurobiology,” he said, “where we tried to understand how pain sensory neurons are activated. That was my apprenticeship in how calcium and other ions enter cells, and how cells perceive and respond to signals.” His laboratory made a landmark discovery in 2006, when they studied a protein, ORAI1, that was mutated in two children with immune deficiency, making the children unusually susceptible to life-threatening infections. Dr. Hogan related the immune deficiency directly to calcium by showing that ORAI1 forms the pore of the calcium entry channel in T cells. “The hopeful lesson we take from these immunodeficient patients is that it may be possible to develop new therapies for transplant rejection and autoimmune disorders by targeting the calcium channel,” he said.

Featured publications

Sep 30, 2019 Nat Rev Immunol
Defining ‘T cell exhaustion’
Blank CU, Haining WN, Held W, Hogan PG, Kallies A, Lugil E, Lynn RC, Philip M, Rao A, Restifo NP, Schietinger A, Schumacher TN, Schwartzberg PL, Sharpe AH, Speiser DE, Wherry EJ, Youngblood BA, Zehn D
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Lab Members

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From the lab

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