Erica Ollmann Saphire, Ph.D., is a Professor of the La Jolla Institute for Immunology. Her research explains, at the molecular level, how and why viruses are pathogenic and provides the roadmap for medical defense. Her team has solved the structures of the Ebola, Sudan, Marburg, Bundibugyo and Lassa virus glycoproteins, explained how they remodel these structures as they drive themselves into cells, how their proteins suppress immune function and where human antibodies can defeat these viruses.
Prof. Saphire is currently leading a Bill & Melinda Gate Foundation-supported consortium to evaluate antibody therapeutics against SARS-CoV-2 to prevent and treat COVID-19. This consortium, CoVIC (covic.lji.org) analyzes the world’s leading therapeutic candidates side-by-side, and uses LJI’s powerful pair of Titan Krios microscopes for high-resolution analysis of the antibody interactions.
She was also the galvanizing force behind the Viral Hemorrhagic Fever Immunotherapeutic Consortium and is directing this NIAID-supported organization. This consortium, Center of Excellence in Translational Research, unites 44 previously competing academic, industrial and government labs across five continents to understand and provide antibody therapeutics against Ebola, Marburg, Lassa and other viruses. A recent discovery from Instructor Kathryn Hastie revealed why neutralizing antibodies had been so difficult to elicit against Lassa virus, and provided not only the templates for the needed vaccine, but the molecule itself: a Lassa surface glycoprotein engineered to remain in the right conformation to inspire the needed antibody response. This molecule is the basis for international vaccine efforts against Lassa. Other work in their lab reveals how these and other viruses replicate and assemble using a variety of biophysical, biochemical, and immunological methods.
Dr. Saphire’s work has been recognized at the White House with the Presidential Early Career Award in Science and Engineering, with young investigator awards from the International Congress of Antiviral Research, the American Society for Microbiology, and the MRC Centre for Virus Research in the United Kingdom. She has been awarded a Fulbright Global Scholar fellowship from the United States Department of State and a Mercator Fellowship from Deutsche Forschungsgemeinschaft, to develop international collaborations using cryoelectron microscopy to further global health.
RT @Stahelin_Lab: Self promotion disclaimer! The final version of our J. Biol. Chem. paper on SARS-CoV-2 budding is now available. Perhaps…
From now on, only buy things that are washable, indestructible, or edible. And legos.
Welcome to Two Boys! And Congratulations!
Random acts of art in the sand -Cardiff, CA
Put it on a kid to record their trajectory around the house. It will be fun to watch when they’re grown and gone.
RT @CVRinfo: *New Vacancies* 2 Senior Lecturer/Professors to lead research programmes supported by the CVR’s quinquennial core award from t…
Had my boys in the same places doing the same thing not so long ago!
RT @slschendel: Ice pack for a #covic shipment to Galit Alter's group at @ragoninstitute. Wish I could find more of these packs because al…
RT @ljiresearch: The next gen of immunologists is working for a future where pandemics can't shut us down. Michael Norris, Ph.D., from the…
After 26 years of dating me and being married to me, my Californian/British husband just let the word y’all slip out of his mouth in normal conversation. I am so happy- you have no idea.
From the lab
To speed inoculations, the U.S. plans to release all available vaccine doses and open access to anyone over 65. Others suggest straying from recommended doses or intentionally delaying boosters. The best way forward remains uncertain.
San Diego scientists and trial participants are cautiously optimistic after early reports that Pfizer’s COVID-19 vaccine is highly effective
Awards & Honors
- Fulbright Global Scholar Award, 2019-2020
- Mercator Fellowship, DFG, Philipps Universitaet Marburg, 2018
- Eli Lilly and Company-Elanco Research Award, American Society for Microbiology, 2016
- Finalist, Classy Award for the Most Innovative Nonprofits and Social Enterprises of 2016 for VIC, 2016
- "Cool Woman", Girl Scouts San Diego, 2016
- William Prusoff Young Investigator Award, Int. Society for Antiviral Research, 2015
- Young Investigator Award, ASBMB, 2015
- Fellow, American Association for the Advancement of Science, 2015
- Fellow, American Academy of Microbiology, 2014
- Presidential Early Career Award in Science and Engineering, 2009
- Investigator in the Pathogenesis of Infectious Disease, Burroughs Wellcome Fund, 2009-2015
- ICAAC Young Investigator Award, American Society for Microbiology, 2006
- Career Award in the Biomedical Sciences, Burroughs Wellcome Fund, 2003-2008
- New Initiatives Award in Global Infectious Disease, Ellison Medical Foundation, 2003
- Surhain Sidhu Award, 2003