Erica Ollmann Saphire, Ph.D., is a Professor of the La Jolla Institute for Immunology. Her research explains, at the molecular level, how and why viruses are pathogenic and provides the roadmap for medical defense. Her team has solved the structures of the Ebola, Sudan, Marburg, Bundibugyo and Lassa virus glycoproteins, explained how they remodel these structures as they drive themselves into cells, how their proteins suppress immune function and where human antibodies can defeat these viruses.
Prof. Saphire is currently leading a Bill & Melinda Gate Foundation-supported consortium to evaluate antibody therapeutics against SARS-CoV-2 to prevent and treat COVID-19. This consortium, CoVIC (covic.lji.org) analyzes the world’s leading therapeutic candidates side-by-side, and uses LJI’s powerful pair of Titan Krios microscopes for high-resolution analysis of the antibody interactions.
She was also the galvanizing force behind the Viral Hemorrhagic Fever Immunotherapeutic Consortium and is directing this NIAID-supported organization. This consortium, Center of Excellence in Translational Research, unites 44 previously competing academic, industrial and government labs across five continents to understand and provide antibody therapeutics against Ebola, Marburg, Lassa and other viruses. A recent discovery from Instructor Kathryn Hastie revealed why neutralizing antibodies had been so difficult to elicit against Lassa virus, and provided not only the templates for the needed vaccine, but the molecule itself: a Lassa surface glycoprotein engineered to remain in the right conformation to inspire the needed antibody response. This molecule is the basis for international vaccine efforts against Lassa. Other work in their lab reveals how these and other viruses replicate and assemble using a variety of biophysical, biochemical, and immunological methods.
Dr. Saphire’s work has been recognized at the White House with the Presidential Early Career Award in Science and Engineering, with young investigator awards from the International Congress of Antiviral Research, the American Society for Microbiology, and the MRC Centre for Virus Research in the United Kingdom. She has been awarded a Fulbright Global Scholar fellowship from the United States Department of State and a Mercator Fellowship from Deutsche Forschungsgemeinschaft, to develop international collaborations using cryoelectron microscopy to further global health.
Donating blood uses 650 calories. That kind of calorie burn is a good thing when you’re faced with a whole pumpkin pie and a small household. Supplies are low due to COVID-19. What CAN you do in a very bad year? You can do this. Make an appt., save a life. sandiegobloodbank.org
I defended my dissertation 20 years ago this week. That went by fast. It's pdb 1HZH - crystal structure of a human IgG1 that assembled into a hexameric array. We think the ring illustrates the landing platform for C1q of the complement cascade.
Damn good advice. twitter.com/RubinsteinJohn…
Twitter, I have a young colleague with antibody and virus CryoEM and X-ray expertise, interested in a structural biology postdoc in the New York City area, perhaps summer 2021, perhaps an industry postdoc. I’d sure be grateful for your ideas and suggestions.
From the lab
San Diego scientists and trial participants are cautiously optimistic after early reports that Pfizer’s COVID-19 vaccine is highly effective
LA JOLLA, CA—Ever since SARS-CoV-2 first appeared, researchers have been trying to understand whether sometimes the immune system does more
LA JOLLA—The National Institute of Allergy and Infectious Diseases (NIAID), one of the National Institutes of Health, has awarded more
Awards & Honors
- Fulbright Global Scholar Award, 2019-2020
- Mercator Fellowship, DFG, Philipps Universitaet Marburg, 2018
- Eli Lilly and Company-Elanco Research Award, American Society for Microbiology, 2016
- Finalist, Classy Award for the Most Innovative Nonprofits and Social Enterprises of 2016 for VIC, 2016
- "Cool Woman", Girl Scouts San Diego, 2016
- William Prusoff Young Investigator Award, Int. Society for Antiviral Research, 2015
- Young Investigator Award, ASBMB, 2015
- Fellow, American Association for the Advancement of Science, 2015
- Fellow, American Academy of Microbiology, 2014
- Presidential Early Career Award in Science and Engineering, 2009
- Investigator in the Pathogenesis of Infectious Disease, Burroughs Wellcome Fund, 2009-2015
- ICAAC Young Investigator Award, American Society for Microbiology, 2006
- Career Award in the Biomedical Sciences, Burroughs Wellcome Fund, 2003-2008
- New Initiatives Award in Global Infectious Disease, Ellison Medical Foundation, 2003
- Surhain Sidhu Award, 2003