During the course of the above-mentioned study, they found interactions between Btk and protein kinase C (PKC)-b and terreic acid as a novel Btk inhibitor that blocked Btk-PKC-b interactions. Their study also showed that PKC-b and Akt are essential for degranulation and cytokine production via activation of several transcription factors. These studies established how cytokine production is regulated by FceRI-stimulated mast cells.
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Kawakami, Y., Kitaura, J., Hartman, S. E., Lowell, C. A., Siraganian, R. P., and Kawakami, T.
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Kawakami, Y., Kitaura, J., Yao, L., McHenry, R. W., Kawakami, Y., Newton, A. C., Kang, S., Kato, R. M., Leitges, M., Rawlings, D. J., and Kawakami, T. A Ras activation pathway dependent on Syk phosphorylation of protein kinase C. Proc. Natl. Acad. Sci. USA. 100:9470-9475, 2003.