COVID-19 and T cells: Single-cell transcriptomic analysis of SARS-CoV-2-reactive CD8 + and CD4 + T cells.


As the SARS-CoV-2 related disease COVID-19 hit hard and changed the lives of every person on earth, the Vijayanand lab recently started to put their expertise in single-cell analysis of T cells responding to SARS-CoV-2 and other respiratory viruses.

Selected References

Meckiff BJ, Ramírez-Suástegui C, Fajardo V, Chee SJ, Kusnadi A, Simon H, Grifoni A, Pelosi E, Weiskopf D, Sette A, Ay F, Seumois G, Ottensmeier CH, Vijayanand P. Single-cell transcriptomic analysis of SARS-CoV-2 reactive CD4 + T cells. bioRxiv. 2020 Jun 13:2020.06.12.148916. doi:10.1101/2020.06.12.148916. Preprint. PMID: 32587963

Kusnadi A, Ramírez-Suástegui C, Fajardo V, Chee SJ, Meckiff BJ, Simon H, Pelosi E, Seumois G, Ay F, Vijayanand P*, Ottensmeier CH*. *corresponding authors. Severely ill COVID-19 patients display augmented functional properties in SARS-CoV-2-reactive CD8 + T cells. bioRxiv. 2020 Jul 10:2020.07.09.194027. doi: 10.1101/2020.07.09.194027. Preprint. – under review Nature Biotechnology.


NIH/NIAID, U19AI14273-S1
Functional and dysfunctional human CD4 T cell and B cell responses to bacteria and viruses

NIH/NIAID, U19AI142742-02
Cooperative Centers on Human Immunology: Biology of human cytotoxic cd4 t cells (CD4-CTLs) in viral infections