Epigenetic and Transcriptomic Profile of Human Immune Cells

The lab aims to perform epigenetic and transcriptomic analyses of purified circulating immune cell types from healthy human subjects.

NIH/NIAID (R24AI08564)

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Reina
How can we enhance tissue immunity?

As the mechanistic principles guiding tissue immunity unfold, the Reina Laboratory will focus on leveraging immune engineering technologies to enhance

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Reina
How is the tissue context enabling TRM-driven immunity?

Spatial transcriptomics at single-molecule resolution allows in situ measurements of hundreds to thousands of genes in large areas of tissues,

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Reina
What are the tissue-specific intrinsic adaptations of TRM?

Long-term tissue residency is a complex, context-dependent challenge requiring specific cellular adaptation strategies. Our recent work has identified common metabolic

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