Neurodegenerative Diseases

The aim of this work funded by Aligning Science Across Parkinson’s (ASAP), in collaboration with Dr. Alessandro Sette, is to investigate T cell reactivity and disease progression in Parkinson’s disease. We are also interested in characterizing T cell reactivity in Alzheimer’s disease, ALS and other neurodegenerative diseases.


Selected publications:

Singhania et al., The TCR repertoire of α-synuclein-specific T cells in Parkinson’s disease is surprisingly diverse, Sci Rep, 2021

Harms et al., Inflammation in Experimental Models of α-Synucleinopathies, Mov Disord, 2021

Dhanwani et al., T Cell Responses to Neural Autoantigens Are Similar in Alzheimer’s Disease Patients and Age-Matched Healthy Controls, Front Neurosci, 2020

Lindestam Arlehamn et al., α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease, Nature Commun, 2020

Lindestam Arlehamn et al., Roles for the adaptive immune system in Parkinson’s and Alzheimer’s diseases, Curr Opin Immunol, 2019

Lindestam Arlehamn et al., Widespread Tau-Specific CD4 T Cell Reactivity in the General Population, J Immunol, 2019

Garretti et al., Autoimmunity in Parkinson’s Disease: The Role of α-Synuclein-Specific T Cells, Front Immunol, 2019

Sulzer et al., T cells from patients with Parkinson’s disease recognize α-synuclein peptides, Nature, 2017