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Neurodegenerative Diseases

The aim of this work funded by Aligning Science Across Parkinson’s (ASAP), in collaboration with Dr. Alessandro Sette, is to investigate T cell reactivity and disease progression in Parkinson’s disease. We are also interested in characterizing T cell reactivity in Alzheimer’s disease, ALS and other neurodegenerative diseases.

 

Selected publications:

Singhania et al., The TCR repertoire of α-synuclein-specific T cells in Parkinson’s disease is surprisingly diverse, Sci Rep, 2021
https://pubmed.ncbi.nlm.nih.gov/33432042/

Harms et al., Inflammation in Experimental Models of α-Synucleinopathies, Mov Disord, 2021
https://pubmed.ncbi.nlm.nih.gov/33009855/

Dhanwani et al., T Cell Responses to Neural Autoantigens Are Similar in Alzheimer’s Disease Patients and Age-Matched Healthy Controls, Front Neurosci, 2020
https://pubmed.ncbi.nlm.nih.gov/32982670/

Lindestam Arlehamn et al., α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease, Nature Commun, 2020
https://pubmed.ncbi.nlm.nih.gov/32313102/

Lindestam Arlehamn et al., Roles for the adaptive immune system in Parkinson’s and Alzheimer’s diseases, Curr Opin Immunol, 2019
https://pubmed.ncbi.nlm.nih.gov/31430650/

Lindestam Arlehamn et al., Widespread Tau-Specific CD4 T Cell Reactivity in the General Population, J Immunol, 2019
https://pubmed.ncbi.nlm.nih.gov/31085590/

Garretti et al., Autoimmunity in Parkinson’s Disease: The Role of α-Synuclein-Specific T Cells, Front Immunol, 2019
https://pubmed.ncbi.nlm.nih.gov/30858851/

Sulzer et al., T cells from patients with Parkinson’s disease recognize α-synuclein peptides, Nature, 2017
https://pubmed.ncbi.nlm.nih.gov/28636593/