Other Diseases – Sette

Varicella Zoster Virus:
Research into the longevity of vaccine-induced immunity to varicella zoster virus, the pathogen that causes chicken pox and shingles.

Staphylococcus Aureus:
Research into how to overcome recurrent Staphylococcus aureus infections, which are driven by differences in MHC-restricted immunodominance. The research has helped define how host genetics determine whether immunity elicited by S. aureus is protective and provide a mechanistic roadmap for future vaccine design.

Harnessing the Immune Epitope Database and Analysis Resources (IEDB) (www.iedb.org) to capture epitope related data on antibody and T cell epitopes of influenza A viruses.

Selected References
Eberhardt CS, Wieland A, Nasti TH, Grifoni A, Wilson E, Schmid DS, Pulendran B, Sette A, Waller EK, Rouphael N, Ahmed R. Persistence of varicella zoster virus specific plasma cells in adult human bone marrow following childhood vaccination. J Virol. 2020 Apr 22:JVI.02127-19. doi: 10.1128/JVI.02127-19. Online ahead of print. PMID: 32321817

Si Y, Zhao F, Beesetty P, Weiskopf D, Li Z, Tian Q, Alegre ML, Sette A, Chong AS, Montgomery CP. Inhibition of protective immunity against Staphylococcus aureus infection by MHC-restricted immunodominance is overcome by vaccination. Sci Adv. 2020 Apr 1;6(14):eaaw7713. doi: 10.1126/sciadv.aaw7713. eCollection 2020 Apr. PubMed PMID: 32270029; PubMed Central PMCID: PMC7112766.

Wu T, Guan J, Handel A, Tscharke DC, Sidney J, Sette A, Wakim LM, Sng XYX, Thomas PG, Croft NP, Purcell AW, La Gruta NL. Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses. Nat Commun. 2019 Jun 28;10(1):2846. doi: 10.1038/s41467-019-10661-8. PubMed PMID: 31253788; PubMed Central PMCID: PMC6599079.

Davis CW, Jackson KJL, McElroy AK, Halfmann P, Huang J, Chennareddy C, Piper AE, Leung Y, Albariño CG, Crozier I, Ellebedy AH, Sidney J, Sette A, Yu T, Nielsen SCA, Goff AJ, Spiropoulou CF, Saphire EO, Cavet G, Kawaoka Y, Mehta AK, Glass PJ, Boyd SD, Ahmed R. Longitudinal Analysis of the Human B Cell Response to Ebola Virus Infection. Cell. 2019 May 30;177(6):1566-1582.e17. doi: 10.1016/j.cell.2019.04.036. Epub 2019 May 16. PubMed PMID: 31104840; PubMed Central PMCID: PMC6908968

Forsyth KS, DeHaven B, Mendonca M, Paul S, Sette A, Eisenlohr LC. Poor Antigen Processing of Poxvirus Particles Limits CD4(+) T Cell Recognition and Impacts Immunogenicity of the Inactivated Vaccine. J Immunol. 2019 Mar 1;202(5):1340-1349. doi: 10.4049/jimmunol.1801099. Epub 2019 Jan 30. PubMed PMID: 30700590; PubMed Central PMCID: PMC6394857.

Croft NP, Smith SA, Pickering J, Sidney J, Peters B, Faridi P, Witney MJ, Sebastian P, Flesch IEA, Heading SL, Sette A, La Gruta NL, Purcell AW, Tscharke DC. Most viral peptides displayed by class I MHC on infected cells are immunogenic. Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3112-3117. doi: 10.1073/pnas.1815239116. Epub 2019 Feb 4. PubMed PMID: 30718433; PubMed Central PMCID: PMC6386720.

Okada S, Markle JG, Deenick EK, Mele F, Averbuch D, Lagos M, Alzahrani M, Al-Muhsen S, Halwani R, Ma CS, Wong N, Soudais C, Henderson LA, Marzouqa H, Shamma J, Gonzalez M, Martinez-Barricarte R, Okada C, Avery DT, Latorre D, Deswarte C, Jabot-Hanin F, Torrado E, Fountain J, Belkadi A, Itan Y, Boisson B, Migaud M, Arlehamn CSL, Sette A, Breton S, McCluskey J, Rossjohn J, de Villartay JP, Moshous D, Hambleton S, Latour S, Arkwright PD, Picard C, Lantz O, Engelhard D, Kobayashi M, Abel L, Cooper AM, Notarangelo LD, Boisson-Dupuis S, Puel A, Sallusto F, Bustamante J, Tangye SG, Casanova JL. IMMUNODEFICIENCIES. Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations. Science. 2015 Aug 7;349(6248):606-613. doi: 10.1126/science.aaa4282. Epub 2015 Jul 9. PubMed PMID: 26160376; PubMed Central PMCID: PMC4668938.

Locci M, Havenar-Daughton C, Landais E, Wu J, Kroenke MA, Arlehamn CL, Su LF, Cubas R, Davis MM, Sette A, Haddad EK; International AIDS Vaccine Initiative Protocol C Principal Investigators, Poignard P, Crotty S. Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses. Immunity. 2013 Oct 17;39(4):758-69. doi: 10.1016/j.immuni.2013.08.031. Epub 2013 Sep 12. PubMed PMID: 24035365; PubMed Central PMCID: PMC3996844.