Unmasking the pancreas
No one knows exactly what triggers type 1 diabetes, but researchers at La Jolla Institute for Immunology have uncovered some fascinating clues.
LJI research leads to promising combination therapy for type 1 diabetes
Phase 2 trial run by Novo Nordisk emphasizes the importance of translational research
Diabetes researchers spot dangerous T cells in the pancreas—even in healthy people
LA JOLLA—Your pancreas is studded with cell clusters called islets. In most people, special beta cells live snug in the
Blocking nerve signals to the pancreas halts type 1 diabetes onset in mice
LA JOLLA—Your pancreas is a little sweet potato-shaped organ that sits snug behind your stomach. The pancreas is studded with
Neuro-immune crosstalk in the pancreas during onset of type 1 diabetes
Team: Gustaf Christoffersson The histopathologic features of human type 1 diabetes are remarkably heterogeneous throughout the pancreas. One lobule of
Modeling and detection of viral infections in human pancreas slices
Team: Mehdi Benkahla It is thought that an interaction between predisposing genes and environmental factors, such as viral infections, may
Characterization of HLA class I expression in autoantibody positive and type 1 diabetic donors
Team: Mehdi Benkahla and Somayeh Sabouri Type 1 diabetes (T1D) is an autoimmune disease characterized by increased blood glucose levels
Detailed in-situ characterization of cytokines, immune and endocrine cell in the human pancreas
Team: Sakthi Rajendran, Estefania Quesada-Masachs, Christine Bender Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction of
Characterization of in-situ IL17 expression in human pancreas
Team: Sakthi Rajendran, Estefania Quesada-Masachs and Mehdi Benkahla IL-17 is a pro-inflammatory cytokine important in shaping host immune responses against
Expression of HLA class II in human pancreatic tissue sections
Team: Estefania Quesada-Masachs, Sakthi Rajendran Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing β cells are attacked
Exploring toxic effects of T1D patient’s serum in pancreatic β cells
Team: Estefania Quesada-Masachs, Sakthi Rajendran Type 1 diabetes (T1D), an autoimmune disease that usually affects young people, is on the
Characterization of specificity and phenotype of pancreatic CD8 T cells in human Type 1 Diabetes
Team: Christine Bender A better understanding of type 1 diabetes (T1D) is the first step to potentially developing new therapies