Overview
Sujan Shresta, Ph.D., and her team study the immunology and pathogenesis of human viruses such as the flaviviruses dengue virus (DENV) and Zika virus (ZIKV) and the coronavirus SARS-CoV-2. DENV causes a spectrum of clinical disease ranging from dengue fever, a self-limited febrile illness, to life-threatening syndromes called severe dengue or dengue hemorrhagic fever/dengue shock syndrome. ZIKV has been proven to cause serious birth defects, and is also associated with neurological conditions including Guillain-Barré Syndrome and meningoencephalitis. In addition to causing the common cold, three coronavirus public health threats have emerged in the last two decades including the SARS-CoV-2 virus that causes COVID-19. Importantly, the human immune system displays “cross-reactivity” within the coronavirus and flavivirus families—the immune response against one virus may affect the future immune response and disease outcome during infection with another virus in the same family.
Collaborating with both academic and industry partners, our laboratory uses state-of-the-art mouse models and human cell cultures to study virus-host interactions, define mechanisms of viral pathogenesis and immunity, and test vaccines and therapeutics. The findings in these studies are validated by studying human samples from endemic countries including Nepal, Thailand, Vietnam, and Japan. In turn, these human studies generate new hypotheses, many of which can only be tested in mouse and human cell culture models.
Featured publications
Mapping and role of the CD8+ T cell response during primary zika virus infection in mice
Human coronavirus OC43-elicited CD4+ T cells protect against SARS-CoV-2 in HLA transgenic mice
Lab Members
Sujan Shresta, Ph.D.
Professor Center for Sex-based Differences in the Immune System, Center for Vaccine InnovationFrom the lab
Common cold or COVID-19? Some T cells are ready to combat both
LA JOLLA, CA—Scientists at La Jolla Institute for Immunology (LJI) have found direct evidence that exposure to common cold coronaviruses
LJI-led team wins top Nucleate honors for virus vaccine development proposal
LA JOLLA, CA—A San Diego team, led by scientists at La Jolla Institute for Immunology (LJI), has won the top
LJI Instructor Annie Elong Ngono, Ph.D., wins GVN support to advance infectious disease research
LA JOLLA—As an infectious disease researcher at La Jolla Institute for Immunology (LJI) Instructor Annie Elong Ngono, Ph.D., has spearheaded
Awards & Honors
- The Blasker Award from the San Diego Foundation, 2008
- Research Scholar Development award from the NIAID, 2005