Designing Vaccines: Differentiation and Function of Follicular Helper CD4 T Cells (Tfh Cells)
A video lecture on Tfh cell biology can be seen here. Germinal centers are the critical sites for the development
Structural Cells
Non-lymphoid structural cells of tissues are recipients of inflammatory signals from immune cells, but they also make inflammatory products that
T Cells
T cells are central to almost all immune responses. The CD4 subset is capable of directing B cell responses and
Regulation of mucosal immunity by stromal cells and dendritic cells crosstalk in the gut
Genetic regulation by vitamin A is involved in multiple biological processes such as embryonic development, vision, and immunity. To exert
The Contribution of Central and/or Peripheral Tolerance in Celiac Disease
Celiac Disease (CD) is an autoimmune-like inflammatory disease induced by aberrant immune responses initiated by MHC class II restricted CD4
Mucosal CD4- CD8- T Cells
One large subgroup of specialized T cells is encompassed by the intraepithelial T cells which are located in the epithelium
Role of Pre-TCR Signaling in Central Tolerance and Autoimmunity?
Autoimmunity is a self-destructive disease condition mediated mainly by pathogenic selfreactive αβ T cell receptor (TCR) expressing T lymphocytes. Self-tolerance
Mechanisms Involved in The Generation of High Affinity Effector Memory T Cells
A hallmark of immune memory is that repeated infections are met with accelerated or/and enhanced protective immunity. Furthermore, unlike naive
CD4+ Cytotoxic Lymphocytes
MHC class-II restricted CD4+ T cytotoxic cells (CD4 CTL) are among the best examples of extreme measures the immune system
T Cell Function
We are now trying to elucidate the regulatory functions displayed by the self-specific agonist selected T cells and their role
T Cells
One large subgroup of these specialized T cells is encompassed by the IEL which are located in the epithelium of
The Lymphotoxin-Interferon Antiviral Immunity Axis
Over the last 15 years our lab has been studying the link between lymphotoxins (LT) and the regulation of type