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Support

Publications

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Jan 26, 2011 Proc Natl Acad Sci U S A
Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3′ to 5′ exonuclease activity essential for immune suppression.
Hastie KM, Kimberlin CR, Zandonatti MA, MacRae IJ, Saphire EO.
Dec 19, 2009 Proc Natl Acad Sci U S A
Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression.
Kimberlin CR, Bornholdt ZA, Li S, Woods VL Jr, MacRae IJ, Saphire EO.
Nov 20, 2009 Acta Crystallogr D Biol Crystallogr
Techniques and tactics used in determining the structure of the trimeric ebolavirus glycoprotein.
Lee JE, Fusco ML, Abelson DM, Hessell AJ, Burton DR, Saphire EO.
Jun 30, 2009 Curr Opin Struct Biol
Neutralizing ebolavirus: structural insights into the envelope glycoprotein and antibodies targeted against it.
Lee JE, Saphire EO.
Apr 18, 2009 Nat Protoc
An efficient platform for screening expression and crystallization of glycoproteins produced in human cells.
Lee JE, Fusco ML, Saphire EO.
Jan 1, 2009 Future Virol
Ebolavirus glycoprotein structure and mechanism of entry.
Lee JE, Saphire EO.
Jul 11, 2008 Nature
Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor.
Lee JE, Fusco ML, Hessell AJ, Oswald WB, Burton DR, Saphire EO.
Nov 17, 2007 J Mol Biol
Complex of a protective antibody with its Ebola virus GP peptide epitope: unusual features of a V lambda x light chain.
Lee JE, Kuehne A, Abelson DM, Fusco ML, Hart MK, Saphire EO.
Apr 21, 2007 J Mol Biol
Structure of a high-affinity “mimotope” peptide bound to HIV-1-neutralizing antibody b12 explains its inability to elicit gp120 cross-reactive antibodies.
Saphire EO, Montero M, Menendez A, van Houten NE, Irving MB, Pantophlet R, Zwick MB, Parren PW, Burton DR, Scott JK, Wilson IA.
May 16, 2006 J Virol
Ebola virus VP35 protein binds double-stranded RNA and inhibits alpha/beta interferon production induced by RIG-I signaling.
Cárdenas WB, Loo YM, Gale M Jr, Hartman AL, Kimberlin CR, Martínez-Sobrido L, Saphire EO, Basler CF
Jan 13, 2004 Adv Exp Med Biol
The carbohydrate epitope of the neutralizing anti-HIV-1 antibody 2G12.
Scanlan CN, Pantophlet R, Wormald MR, Saphire EO, Calarese D, Stanfield R, Wilson IA, Katinger H, Dwek RA, Burton DR, Rudd PM.
Jan 13, 2004 Adv Exp Med Biol
Crystal structure of an intact human IgG: antibody asymmetry, flexibility, and a guide for HIV-1 vaccine design.
Saphire EO, Stanfield RL, Crispin MD, Morris G, Zwick MB, Pantophlet RA, Parren PW, Rudd PM, Dwek RA, Burton DR, Wilson IA.
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