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Publications

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Jul 23, 2019 MBio
Sudan ebolavirus VP35-NP crystal structure reveals a potential target for pan-filovirus treatment
Landeras-Bueno S, Oda SI, Norris MJ, Li Salie Z, Guenaga J, Wyatt RT, Saphire EO
May 30, 2019 Cell
Longitudinal analysis of the human B cell response to ebola virus infection
Davis CW, Jackson KJL, McElroy AK, Halfmann P, Huang J, Chennareddy C, Piper AE, Leung Y, Albarino CG, Crozier I, Ellebedy AH, Sidney J, Sette A, Yu T, Nielsen SCA, Coff AJ, Spiropoulou CF, Saphire EO, Cavet G, Kawaoka Y, Mehta AK, Glass PJ, Boyd SD, Ahmed R
Apr 7, 2019 Nat Commun
Cross-reactive neutraliing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk
King LB, West BR, Moyer CL, Gilchuk P, Flyak A, Ilinykh PA, Bombardi R, Hui S, Huang K, Bukreyev A, Crowe JE Jr, Saphire EO
Feb 26, 2019 Structure
A Conserved Basic Patch and Central Kink in the Nipah Virus Phosphoprotein Multimerization Domain Are Essential for Polymerase Function.
Bruhn JF, Hotard AL, Spiropoulou CF, Lo MK, Saphire EO.
Feb 8, 2019 J Virol
Early human B cell response to Ebola virus in four U.S. survivors of infection.
Williamson L, Flyak AI, Kose N, Bombardi R, Branchizio A, Reddy S, Davidson E, Doranz B, Fusco ML, Saphire EO, Halfmann PJ, Kawaoka Y, Piper AE, Glass PJ, Crowe JE Jr.
Nov 15, 2018 Cell Rep
In Vivo Delivery of Synthetic Human DNA-Encoded Monoclonal Antibodies Protect against Ebolavirus Infection in a Mouse Model.
Patel A, Park DH, Davis CW, Smith TRF, Leung A, Tierney K, Bryan A, Davidson E, Yu X, Racine T, Reed C, Gorman ME, Wise MC, Elliott STC, Esquivel R, Yan J, Chen J, Muthumani K, Doranz BJ, Saphire EO, Crowe JE, Broderick KE, et al.
Oct 20, 2018 Nat Immunol
Antibody-mediated protection against Ebola virus.
Saphire EO, Schendel SL, Gunn BM, Milligan JC, Alter G.
Sep 13, 2018 Mbio
Structural Basis of Pan-Ebolavirus Neutralization by a Human Antibody against a Conserved, yet Cryptic Epitope.
West BR, Moyer CL, King LB, Fusco ML, Milligan JC, Hui S, Saphire EO.
Sep 12, 2018 J Infect Dis
Structural Characterization of Pan-Ebolavirus Antibody 6D6 Targeting the Fusion Peptide of the Surface Glycoprotein.
Milligan JC, Parekh DV, Fuller KM, Igarashi M, Takada A, Saphire EO.
Aug 16, 2018 Cell Rep
Antibody Repertoires to the Same Ebola Vaccine Antigen Are Differentially Affected by Vaccine Vectors.
Meyer M, Yoshida A, Ramanathan P, Saphire EO, Collins PL, Crowe JE Jr, Samal S, Bukreyev A.
Aug 15, 2018 J Infect Dis
Pan-Filovirus Serum Neutralizing Antibodies in a Subset of Congolese Ebolavirus Infection Survivors.
Bramble MS, Hoff N, Gilchuk P, Mukadi P, Lu K, Doshi RH, Steffen I, Nicholson BP, Lipson A, Vashist N, Sinai C, Spencer D, Olinger G, Wemakoy EO, Illunga BK, Pettitt J, Logue J, Marchand J, Varughese J, Bennett RS, Jahrling P, Cavet G, et al.
Aug 11, 2018 Cell
Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection.
Saphire EO, Schendel SL, Fusco ML, Gangavarapu K, Gunn BM, Wec AZ, Halfmann PJ, Brannan JM, Herbert AS, Qiu X, Wagh K, He S, Giorgi EE, Theiler J, Pommert KBJ, Krause TB, Turner HL, Murin CD, Pallesen J, Davidson E, Ahmed R, Aman MJ, et al.
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