Publications

Oct 6, 2020 Nat Rev Immunol

Cross-reactive memory T cells and herd immunity to SARS-CoV-2

Lipsitch M, Grad YH, Sette A, Crotty S

Sep 16, 2020 Cell

Antigen-specific adaptive immunity to SARS-CoV-2 in acute COVID-19 and associations with age and disease severity

Rydyznski Moderbacher C, Ramirez SI, Dan JM, Grifoni A, Hastie KM, Weiskopf D, Belanger S, Abbott RK, Kim C, Choi J, Kato Y, Crotty EG, Kim C, Rawlings SA, Mateus J, Tse LPV, Frazier A, Baric R, Peters B, Greenbaum J, Ollmann Saphire E, Smith DM, Sette A, Crotty S

Sep 15, 2020 PNAS

B cells expressing authentic naive human VRC01-class BCRs can be recruited to germinal centers and affinity mature in multiple independent mouse models

Huang D, Abbott RK, Havenar-Daughton C, Skog PD, Al-Kolla R, Groschel B, Blane TR, Menis S, Tran JT, Thinnes TC, Volpi SA, Pintea M, Voss JE, Philps N, Tingle R, Rodriguez AR, Martin G, Kupryianov S, Schief WR, Nemazee D, Crotty S

Sep 15, 2020 Immunity

Multifaceted effects of antigen valency on B cell response composition and differentiation in vivo

Kato Y, Abbott RK, Freeman BL, Haupt S, Groschel B, Silva M, Menis S, Irvine DJ, Schief WR, Crotty S

Aug 5, 2020 NPJ Vaccines

Targeting HIV Env immunogens to B cell follicles in nonhuman primate through immune complex or protein nanoparticle formulations

Martin JT, Cottrel CAl, Antanasijevic A, Carnathan DG, Cossette BJ, Enemuo CA, Gebru EH, Choe Y, Viviano F, Fischinger S, Tokatlian T, Cirelli KM, Ueda G, Copps J, Schiffner T, Menis S, Alter G, Schief WR, Crotty S, King NP, Baker D, Silvestri G, Ward AB, Irvine DJ

Aug 4, 2020 Science

Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans

Mateus J, Grifoni A, Tarke A, Sidney J, Ramirez SI, Dan JM, Burger ZC, Rawlings SA, Smith DM, Phillips E, Mallal S, Lammers M, Rubiro P, Quiambao L, Sutherland A, Yu ED, da Silva Antunes R, Greenbaum J, Frazier A, Markmann AJ, Premkumar L, de Silva A, Peters B, Crotty S, Sette A, Weiskopf D.

Jul 7, 2020 Nat Rev Immunol

Pre-existing immunity to SARS-CoV-2: the knowns and unknowns

Sette, A., Crotty, S

May 20, 2020 Cell

Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals

Grifoni, A., Weiskopf, D., Ramirez, S.I., Mateus, J., Dan, J.M., Moderbacher, C.R., Rawlings, S.A., Sutherland, A., Premkumar, L., Jadi, R.S., Marrama, D., de Silva, A.M., Frazier, A., Carlin, A., Greenbaum, J.A., Peters, B., Krammer, F., Smith, D.M., Crotty, S., Sette, A.,

Apr 1, 2020 J Immunol Methods

Normal human lymph node T follicular helper cells and germinal center B cells accessed via fine needle aspirations

Havenar-Daughton C, Newton IG, Somaya SY, Reiss SM, Schwan B, Suh MJ, Hastech F, Levi G, Crotty S

Mar 1, 2020 Nat Med

Engineered immunogen binding to alum adjuvant enhances humoral immunity

Moyer TJ, Kato Y, Abraham W, Chang JYH, Kulp DW, Watson N, Turner HL, Menis S, Abbott RK, Bhiman JN, Melo MB, Simon HA, Herrera-De La Mata S, Liang S, Seumois G, Agarawl Y, Li N, Burton DR, Ward AB, Schief WR, Crotty S, Irvine DJ

Dec 6, 2019 Cell Reports

Rapid germinal center and antibody responses in non-human primates after a single nanoparticle vaccine immunization

Havenar-Daughton C, Carnathan DG, Boopathy AV, Upadhyay AA, Murrell B, Reiss SM, Enemuo CA, Gebru EH, Choe Y, Dhadvai P, Viviano F, Kaushik K, Bhiman JN, Briney B, Burton DR, Bosinger SE, Schief WR, Irvine DJ, Silvestri G, Crotty S

Dec 6, 2019 Science

A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses

Steichen JM, Lin YC, Havenar-Daughton C, S Pecetta, Ozorowski G, Willis JR, Toy L, Sok D, Liguori A, Kratochvil S, Torres JL, Kalyuzhniy O, Melzi E, Kulp DW, Raemisch S, Hu Z, Bernard SM, Georgeson E, Phelps N, Adachi Y, Kubitz M, Landais E, Umotoy J, Robinson A, Briney B, Wilson I, Burton DR, Ward AB, Crotty S, Batista FD, Schief WR