Dr. Alessandro Sette has devoted more than 35 years of study towards understanding the immune response, measuring immune activity, and developing disease intervention strategies against cancer, autoimmunity, allergy, and infectious diseases. The laboratory is defining in chemical terms the specific structures (epitopes) that the immune system recognizes, and uses this knowledge to measure and understand immune responses.
The Sette lab’s approach uses epitopes as specific probes to define the immune signatures associated with productive/protective immunity versus deficient immunity/immunopathology. This research will improve understanding of how the body successfully battles infection, and conversely, how pathogens escape the immune system, causing the individual to succumb to disease. Because of the laboratory’s success in its study of immune response, Sette and his team believe their research will lead to development of new therapeutic and prophylactic approaches to fighting infectious diseases. In this area, Dr. Sette’s disease focus has shifted over the years from HIV, HBV and HCV to emerging diseases and diseases of potential biodefense concern to, most recently, diseases and pathogens relevant to worldwide global health, including SARS-CoV-2, Dengue, Zika, Chikungunya, malaria, M. tuberculosis, B. pertussis, and shingles. Furthermore, Dr. Sette’s team has adapted the methods and techniques developed in the context of infectious disease to understand the T cell response to common allergens and to discover a cell component in Parkinson’s Disease.
Finally, Dr. Sette has overseen the design and curation efforts of the national Immune Epitope Database (IEDB), a freely available, widely used bioinformatics resource, since its inception in the early 2000s. The IEDB catalogs all epitopes for humans, non-human primates, rodents, and other vertebrates, from allergens, infectious diseases, autoantigens and transplants, and includes epitope prediction tools to accelerate immunology research around the world.
A sequence homology and bioinformatics approach can predict candidate tagets for immune responses in SARS-CoV-2
Cockroach Allergy: The Sette lab is working to identify the sites on allergen molecules that trigger an inflammatory immune response.
ATHEROSCLEROSIS Working in collaboration with LJI Professor Klaus Ley, the Sette Lab aims to help develop vaccines that target inflammatory
The Sette lab’s previous large scale epitope identification efforts (supported by HHS contracts) have led to a deeper understanding of
Human Immune Profiling Consortium
The aim of this work, in collaboration with Bjoern Peters, Ph.D., and Pandurangan Vijayanand, M.D., Ph.D., is to characterize the
Immune Epitope Database and Analysis Resource Program
A collaboration with LJI Professor Alessandro Sette, Dr. Biol. Sci, to maintain and further develop the Immune Epitope Database (IEDB) and associated
Other Diseases – Sette
Varicella Zoster Virus: Research into the longevity of vaccine-induced immunity to varicella zoster virus, the pathogen that causes chicken pox
From the lab
Antibodies can change to counter new forms of the shape-shifting virus, research hints
People who have already been sick with Covid-19 should still be vaccinated, experts say, but they may experience intense side effects even after one dose.