Expression of HLA class II in human pancreatic tissue sections
Team: Estefania Quesada-Masachs, Sakthi Rajendran Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing β cells are attacked
Exploring toxic effects of T1D patient’s serum in pancreatic β cells
Team: Estefania Quesada-Masachs, Sakthi Rajendran Type 1 diabetes (T1D), an autoimmune disease that usually affects young people, is on the
Characterization of specificity and phenotype of pancreatic CD8 T cells in human Type 1 Diabetes
Team: Christine Bender A better understanding of type 1 diabetes (T1D) is the first step to potentially developing new therapies
Molecular Mechanisms Underlying Novel Interferonopathies
In addition to their protective role against microbial pathogens and neoplastic cells, high levels of circulating type I Interferon are
Targeting Tumor Endothelium for Cancer Surveillance and Immunotherapy
Preliminary data from our lab shows that vascular endothelial cells (vECs) mount remarkably potent innate responses to cell-free DNA, which
New Molecular Players in the cGAS-STING Pathway of Anti-Viral and Anti-Tumor Defense
Cell-free, immuno-stimulatory DNA is recognized in the cytoplasm of cells as a universal danger signal by the innate immune system.
Other Diseases – Sette
Varicella Zoster Virus: Research into the longevity of vaccine-induced immunity to varicella zoster virus, the pathogen that causes chicken pox
Pertussis
Immunological Basis of Differences in Protection Between Pertussis Vaccines: The recent increase in cases of whooping cough among teenagers in
Parkinson’s
The lab investigates T cell reactivity and disease progression in Parkinson’s disease. Findings suggest immune cells are responsible for disease
Allergy
Cockroach Allergy: The Sette lab is working to identify the sites on allergen molecules that trigger an inflammatory immune response.
Dengue Virus
The Sette lab’s previous large scale epitope identification efforts (supported by HHS contracts) have led to a deeper understanding of
Tuberculosis
T cell responses to Mycobacterium tuberculosis infection and vaccination: Following completion of a massive epitope discovery effort (also supported by