von Herrath
Characterization of specificity and phenotype of pancreatic CD8 T cells in human Type 1 Diabetes

Team: Christine Bender A better understanding of type 1 diabetes (T1D) is the first step to potentially developing new therapies

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Sharma
Molecular Mechanisms Underlying Novel Interferonopathies

In addition to their protective role against microbial pathogens and neoplastic cells, high levels of circulating type I Interferon are

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Sharma
Targeting Tumor Endothelium for Cancer Surveillance and Immunotherapy

Preliminary data from our lab shows that vascular endothelial cells (vECs) mount remarkably potent innate responses to cell-free DNA, which

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Sharma
New Molecular Players in the cGAS-STING Pathway of Anti-Viral and Anti-Tumor Defense

Cell-free, immuno-stimulatory DNA is recognized in the cytoplasm of cells as a universal danger signal by the innate immune system.

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Sette
Other Diseases – Sette

Varicella Zoster Virus: Research into the longevity of vaccine-induced immunity to varicella zoster virus, the pathogen that causes chicken pox

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Sette
Pertussis

Immunological Basis of Differences in Protection Between Pertussis Vaccines: The recent increase in cases of whooping cough among teenagers in

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Sette
Parkinson’s

The lab investigates T cell reactivity and disease progression in Parkinson’s disease. Findings suggest immune cells are responsible for disease

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Sette
Allergy

Cockroach Allergy: The Sette lab is working to identify the sites on allergen molecules that trigger an inflammatory immune response.

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Sette
Dengue Virus

The Sette lab’s previous large scale epitope identification efforts (supported by HHS contracts) have led to a deeper understanding of

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Sette
Tuberculosis

T cell responses to Mycobacterium tuberculosis infection and vaccination: Following completion of a massive epitope discovery effort (also supported by

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Sette
SARS-COV-2

Reactivity study: A collaboration between the Sette lab and Shane Crotty, Ph.D., to document acquired immunity to SARS-CoV-2 and help

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Peters
Cancer

Immunotherapies for head and neck cancer: To develop new cancer therapies by studying how the immune system, by way of

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