Characterization of HLA class I expression in autoantibody positive and type 1 diabetic donors

Team: Mehdi Benkahla and Somayeh Sabouri Type 1 diabetes (T1D) is an autoimmune disease characterized by increased blood glucose levels

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Detailed in-situ characterization of cytokines, immune and endocrine cell in the human pancreas

Team: Sakthi Rajendran, Estefania Quesada-Masachs, Christine Bender Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction of

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Characterization of in-situ IL17 expression in human pancreas

Team: Sakthi Rajendran, Estefania Quesada-Masachs and Mehdi Benkahla IL-17 is a pro-inflammatory cytokine important in shaping host immune responses against

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Expression of HLA class II in human pancreatic tissue sections

Team: Estefania Quesada-Masachs, Sakthi Rajendran Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing β cells are attacked

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Exploring toxic effects of T1D patient’s serum in pancreatic β cells

Team: Estefania Quesada-Masachs, Sakthi Rajendran Type 1 diabetes (T1D), an autoimmune disease that usually affects young people, is on the

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von Herrath
Characterization of specificity and phenotype of pancreatic CD8 T cells in human Type 1 Diabetes

Team: Christine Bender A better understanding of type 1 diabetes (T1D) is the first step to potentially developing new therapies

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Sharma
Molecular Mechanisms Underlying Novel Interferonopathies

In addition to their protective role against microbial pathogens and neoplastic cells, high levels of circulating type I Interferon are

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Sharma
Targeting Tumor Endothelium for Cancer Surveillance and Immunotherapy

Preliminary data from our lab shows that vascular endothelial cells (vECs) mount remarkably potent innate responses to cell-free DNA, which

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Sharma
New Molecular Players in the cGAS-STING Pathway of Anti-Viral and Anti-Tumor Defense

Cell-free, immuno-stimulatory DNA is recognized in the cytoplasm of cells as a universal danger signal by the innate immune system.

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Sette
Other Diseases – Sette

Varicella Zoster Virus: Research into the longevity of vaccine-induced immunity to varicella zoster virus, the pathogen that causes chicken pox

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Sette
Pertussis

Immunological Basis of Differences in Protection Between Pertussis Vaccines: The recent increase in cases of whooping cough among teenagers in

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Sette
Parkinson’s

The lab investigates T cell reactivity and disease progression in Parkinson’s disease. Findings suggest immune cells are responsible for disease

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