Mucosal Immunology and IBD
A major area of research in our laboratory is the regulation of mucosal immunity. We have collaborated extensively with the
NKT Cell Immunology
Vα14 invariant NKT (Vα14 iNKT) cells are a population of T lymphocytes that have several unique characteristics; many of these
IgE Heterogeneity
Since their finding of ‘monomeric IgE effects’ on mast cell survival in 2001, Dr. Kawakami and associates have shown that
Phospholipase C (PLC)-B3-Mediated Regulation of Stat5 Activity
Given their previous studies on crosstalks between PTKs-dependent and G protein-coupled receptor-dependent signals in FceRI-stimulated mast cells, they have been
Mouse Model of Atopic Dermatitis (AD)
As our knowledge of the FceRI-mediated signal transduction has grown for the last two decades, the need to study in
Btk-Mediated Regulation of Cytokine Production
During the course of the above-mentioned study, they found interactions between Btk and protein kinase C (PKC)-b and terreic acid
Bruton’s Tyrosine Kinase (Btk) in Mast Cell Activation
Dr. Kawakami has been using the high-affinity IgE receptor (FceRI) signaling in mast cells as a model system. Following his
Regulation of Treg Function in Cardiovascular Disease
Epigenetic Regulation of Neutrophil and Monocyte Development in Disease
Immunoprofiling of Human Immune Cells in Cardiovascular Disease and Cancer
CD8 T Cell Functions in Atherosclerosis
HIV Vaccine Research (AIDS Vaccine Research)
Broadly neutralizing antibodies have been discovered in ~5% of HIV+ individuals. Some of those antibodies (HIV bnAbs) are capable of