T Cell Function
We are now trying to elucidate the regulatory functions displayed by the self-specific agonist selected T cells and their role
T Cells
One large subgroup of these specialized T cells is encompassed by the IEL which are located in the epithelium of
The Lymphotoxin-Interferon Antiviral Immunity Axis
Over the last 15 years our lab has been studying the link between lymphotoxins (LT) and the regulation of type
CMV Targets the Immune Checkpoint Inhibitor BTLA
Virulent isolates of CMV encode the ul144 orf, and we identified UL144 as an orthologue of the herpesvirus entry mediator
T Cell Immunity and CMV
HCMV-specific CD8 T cells protect bone marrow transplant patients when used in cellular immunotherapy, and their long-term maintenance is enhanced
CMV Interfaces with The Trail Cytokine System
We have recently discovered a novel connection between the TNF-related apoptosis inducing ligand (TRAIL) cytokine system and CMV. TRAIL is
Epigenomics Session at PSB 2013
Epigenomics Session. Pacific Symposium on Biocomputing 2013 Project Link
Tutorial at ACM-BCB 2015
ACM Conference on Bioinformatics, Computational Biology, and Health Informatics (ACM BCB), 2015 The field of regulatory genomics has recently witnessed
P. Falciparum Epigenetic Gene Regulation
The third dimension of epigenetic gene regulation in the malaria parasite Plasmodium falciparum. Project Link
P. Falciparum 3 D Genome Organization
Three-dimensional modeling of the P. falciparum genome during the erythrocytic cycle reveals a strong connection between genome architecture and gene
Fit-Hi-C: Statistical Confidence Estimation for Hi-C Data
Fit-Hi-C is a tool for assigning statistical confidence estimates to intra-chromosomal contact maps produced by genome-wide genome architecture assays such
A Novel CTLA4-Mediated Treg Cell-Intrinsic Signaling Pathway
Recent work by others has provided evidence that, in contrast to conventional T cells, PKCq negatively regulates the suppressive activity