Publications

Jan 21, 2021 Sci Immunol

Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8+ T cells

Kusnadi A, Ramírez-Suástegui C, Fajardo V, Chee SJ, Meckiff BJ, Simon H, Pelosi E, Seumois G, Ay F, Vijayanand P, Ottensmeier CH.

Jan 15, 2021 Sci Immunol

PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques

Kauffman, K.D., Sakai, S., Lora, N.E., Namasivayam, S., Baker, P.J., Kamenyeva, O., Foreman, T.W., Nelson, C.E., Oliveira-de-Souza, D., Vinhaes, C.L., Yaniv, Z., Lindestam Arleham, C.S., Sette, A., Freeman, G.J., Moore, T; NIAID/DIR Tuberculosis Imaging Program, Sher, A., Mayer-Barber, K.D., Andrade, B.B., Kabat, J., Via, L.E., and Barber, D.L.

Jan 15, 2021 J Infect Dis

Differential T cell reactivity to endemic coronaviruses and SARS-CoV-2 in community and health care workers

Da Silva Antunes, R., Pallikkuth, S., Williams, E., Esther, D.Y., Mateus, J., Quiambao, L., Wang, E., Rawlings, S.A., Stadlbauer, D., Jiang, K., Amanat, F., Arnold, D., Andrews, D., Fuego, I., Dan, J.M., Grifoni, A., Weiskopf, D., Krammer, F., Crotty, S., Hoffer, M.E., Pahwa, S.G., and Sette, A.*

Jan 12, 2021 Cell

Adaptive immunity to SARS-CoV-2 and COVID-19

Sette, A.*, and Crotty, S.

Jan 11, 2021 Sci Rep

The TCR repertoire of a-synuclein-specific T cells in Parkinson’s disease is surprisingly diverse

Singhania, A., Pham, J., Dhanwani, R., Frazier, A., Rezende Dutra, J., Marder, K.S., Phillips, E., Mallal, S., Amara, A.W., Standaert, D.G., Sulzer, D., Peters, B., Sette, A.*, and Lindestam Arlehamn, C.S.

Jan 6, 2021 Science

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection

Dan JM, Mateus J, Kato Y, Hastie KM, Yu ED, Faliti CE, Grifoni A, Ramirez SI, Haupt S, Frazier A, Nakao C, Rayaprolu V, Rawlings SA, Peters B, Krammer F, Simon V, Saphire EO, Smith DM, Weiskopf D, Sette A, Crotty S.

Jan 4, 2021 NPJ Vaccines

MTBVAC vaccination protects rhesus macaques against aerosol challenge with M. tuberculosis and induces immune signatures analogous to those observed in clinical studies

White, A.D., Sibley, L., Sarfas, C., Morrison, A., Gullick, J., Clark, S., Gleeson, F., McIntyre, A., Arlehamn, C.L., Sette, A., Salgguero, F.J., Rayner, E., Rodriguez, E., Puentes, E., Laddy, D., Williams, A., Dennis, M., Martin, C., and Sharpe, S.

Dec 21, 2020 Nat Genet

Promoter-interacting expression quantitative trait loci are enriched for functional genetic variants

Chandra V, Bhattacharyya S, Schmiedel BJ, Madrigal A, Gonzalez-Colin C, Fotsing S, Crinklaw A, Seumois G, Mohammadi P, Kronenberg M, Peters B, Ay F, Vijayanand P.

Dec 9, 2020 bioRxiv

Comprehensive analysis of T cell immunodominace and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases

Tarke, A., Sidney, J., Kidd, C.K., Dan, J.M., Ramirez, S.I., Yu, E.D., Mateus, J., da Silva Antunes, R., Moore, E., Rubiro, P., Methot, N., Phillips, E., Mallal, S., Frazier, A., Rawlings, S.A., Greenbaum, J.A., Peters, B., Smith, D.M., Crotty, S., Weiskopf, D., Grifoni, A., and Sette, A.

Dec 8, 2020 Lancet Respir Med

Safety and immunogenicity of the adjunct therapeutic vaccine ID93+ GLA-SE in adult who have completed treatment for tuberculosis: a randomised, double-blind, placebo-controlled, phase 2a trial

Day, T.A., Penn-Nicholson, A., Luabeya, A.K.K., Fiore-Gartland, A., Du Plessis, N., Loxton, A.G., Vergara, J., Rolf, T.A., Reid, T.D., Toefy, A., Shenje, J., Geldenhuys, H., Tameris, M., Mabew, S., Bilek, N., Bekker, L.G., Diacon, A., Walzl, G., Ashman, J., Frevol, A., Sagawa, Z.K., Lindestam Arlehamn, C., Sette, A., Reed, S.G., Coler, R.N., Scriba, T.J., Hatherill, M.; TBVPX-203 study team

Nov 28, 2020 Cytotherapy

In vitro induction of neoantigen-specific T cells in myelodysplastic syndrome, a disease with low mutational burden

Ferrari, V., Tarke, A., Fields, H., Ferrari, L., Conley, T., Ferrari, F., Kosaloglu-Yalcin, Z., Sette, A., Peters, B., McCarthy, C.L., Bashey, A., Tzachanis, D., Ball, E.D., Tanaka, T.N., Bejar, R., Lane, T.A., and Vitiello, A.

Nov 25, 2020 Cell

Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4+ T Cells in COVID-19

Meckiff BJ, Ramírez-Suástegui C, Fajardo V, Chee SJ, Kusnadi A, Simon H, Eschweiler S, Grifoni A, Pelosi E, Weiskopf D, Sette A, Ay F, Seumois G, Ottensmeier CH, Vijayanand P.