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Overview

Millions of Americans suffer from food allergies. Their allergic reactions can range from itching and a slight rash to rapid swelling and deadly anaphylactic shock. Common food allergens are cow’s milk, peanuts, tree nuts, shellfish, eggs, wheat and soy.

Food allergies often begin in childhood. In fact, according to the U.S. Centers for Disease Control and Prevention, 8 percent of children have a food allergy. Nearly half of these children will end up in the emergency room for food allergy treatment at some point.

There is no cure for food allergies. Over-the-counter antihistamines can help treat minor symptoms. Severe reactions require an emergency epinephrine injection and physician evaluation. Recent studies show that oral immunotherapy, where patients receive small doses of the food they are allergic to, may be promising.

Our Approach

Researchers at La Jolla Institute for Immunology (LJI) study the root causes of food allergies with the goal of guiding novel therapeutics.

LJI Professor Toshiaki Kawakami, M.D., Ph.D., and his team study the activity of specific cells found in mucosal and connective tissues, called mast cells, in response to allergens from food. Mast cells can respond to allergens by triggering a range of symptoms and signs—from itching, wheezing, and sneezing to life-threatening anaphylaxis. 

Dr. Kawakami and his colleagues have made progress in dissecting the complex network of signaling molecules involved in the early phase of mast cell activation. During allergic reactions, mast cells can be activated by an immune molecule called immunoglobulin E (IgE). For a long time, scientists believed that allergens ramp up levels of antibodies called immunoglobulin E (or IgE), which then bind to mast cells. They thought that when an allergen touches IgE, mast cells release histamine, the chemical that then drives inflammation and itching.

Dr. Kawakami’s work suggests that allergen levels are often too low to activate mast cells through this pathway. Instead, a 2017 study from his lab shows an important role for a small protein named histamine-releasing factor (HRF). This research confirms that HRF is triggered by allergens to bind to IgE. The two molecules then work together to activate mast cells and boost inflammation.

Dr. Kawakami’s lab is focused on developing potent HRF inhibitors to prevent anaphylaxis and is currently testing them in mouse models.

Research Projects

Peters
Allergic Diseases

Pediatric Milk Allergy: To study the frequency and phenotype of milk allergen-specific T cells in cohorts with different disease manifestations

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Kawakami
IgE Heterogeneity

Since their finding of ‘monomeric IgE effects’ on mast cell survival in 2001, Dr. Kawakami and associates have shown that

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More research projects

Related News

Labs

Jul 8, 2020
Kawakami Lab

Toshiaki Kawakami, M.D., Ph.D., and his team study allergic diseases such as asthma, allergic rhinitis, food allergy, and atopic dermatitis.

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Toshiaki Kawakami, M.D., Ph.D.
Professor
Center for Autoimmunity and Inflammation