Single-cell eQTL analysis of activated T cell subsets reveals activation and cell type–dependent effects of disease-risk variants

Feb 25, 2022 Science Immunology

Single-cell eQTL analysis of activated T cell subsets reveals activation and cell type–dependent effects of disease-risk variants

Benjamin J. Schmiedel,vCristian Gonzalez-Colin, Vicente Fajardo, Job Rocha, Ariel Madrigal, Ciro Ramirez-Suastegui, Sourya Bhattacharyya, Hayley Simon, Jason A. Greenbaum, Bjoern Peters, Gregory Seumois, Ferhat Ay, Vivek Chandra, Pandurangan, Vijayanand

May 3, 2022 Behind the Science

Graduate student Leila Chihab wins prestigious NSF grant

"Everyone is encouraged to apply for this award because it's such a good opportunity, but you are told not to get your hopes up."

Jan 1, 2021 Mol Cell Proteomics.

Allele-specific thresholds of eluted ligands for T-cell epitope prediction.

Reardon B, Koşaloğlu-Yalçın Z, Paul S, Peters B, Sette A.

Jan 1, 2021 Cytokine.

Lack of evidence supporting a role of IFN-β and TGF-β in differential polarization of Bordetella pertussis specific-T cell responses.

da Silva Antunes R, Quiambao LG, Soldevila F, Sutherland A, Peters B, Sette A.

Jan 1, 2021 Nat Genet.

Promoter-interacting expression quantitative trait loci are enriched for functional genetic variants.

Chandra V, Bhattacharyya S, Schmiedel BJ, Madrigal A, Gonzalez-Colin C, Fotsing S, Crinklaw A, Seumois G, Mohammadi P, Kronenberg M, Peters B, Ay F, Vijayanand P.

Feb 16, 2021 Cell Rep Med.

Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases.

Tarke A, Sidney J, Kidd CK, Dan JM, Ramirez SI, Yu ED, Mateus J, da Silva Antunes R, Moore E, Rubiro P, Methot N, Phillips E, Mallal S, Frazier A, Rawlings SA, Greenbaum JA, Peters B, Smith DM, Crotty S, Weiskopf D, Grifoni A, Sette A.

Feb 5, 2021 Science.

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection.

Dan JM, Mateus J, Kato Y, Hastie KM, Yu ED, Faliti CE, Grifoni A, Ramirez SI, Haupt S, Frazier A, Nakao C, Rayaprolu V, Rawlings SA, Peters B, Krammer F, Simon V, Saphire EO, Smith DM, Weiskopf D, Sette A, Crotty S.

Feb 1, 2021 Immunology.

Comparison of HLA ligand elution data and binding predictions reveals varying prediction performance for the multiple motifs recognized by HLA-DQ2.5.

Koşaloğlu-Yalçın Z, Sidney J, Chronister W, Peters B, Sette A.

Jan 11, 2021 Sci Rep.

Functional analysis of immune signature genes in Th1* memory cells links ISOC1 and pyrimidine metabolism to IFN-g and IL-17 production.

Kushnareva Y, Mathews IT, Andreyev AY, Altay G, Lindestam Arlehamn CS, Pandurangan V, Nilsson R, Jain M, Sette A, Peters B, Sharma S.

Peters

Single-cell eQTL analysis of activated T cell subsets reveals activation and cell type–dependent effects of disease-risk variants

Graduate student Leila Chihab wins prestigious NSF grant

Allele-specific thresholds of eluted ligands for T-cell epitope prediction.

Lack of evidence supporting a role of IFN-β and TGF-β in differential polarization of Bordetella pertussis specific-T cell responses.

Promoter-interacting expression quantitative trait loci are enriched for functional genetic variants.

Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases.

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection.

Comparison of HLA ligand elution data and binding predictions reveals varying prediction performance for the multiple motifs recognized by HLA-DQ2.5.

The TCR repertoire of a-synuclein-specific T cells in Parkinson’s disease is surprisingly diverse.

B cells modulate mouse allergen-specific T cells in nonallergic laboratory animal-care workers.

An immunologically friendly classification of non-peptidic ligands.

Functional analysis of immune signature genes in Th1* memory cells links ISOC1 and pyrimidine metabolism to IFN-g and IL-17 production.