Support
Bjoern Peters, Ph.D.
Professor
Center for Infectious Disease and Vaccine Research, Center for Cancer Immunotherapy
"The challenge in bioinformatics for immunology is not to develop faster algorithms, but to accurately translate immunological questions into a computable form."

Overview

Research in the Peters lab is focused in three areas, all relating to the development of computational tools to address fundamental questions in immunology.

Starting as a PhD student in 2000, Dr. Peters has worked on the development and validation of tools to analyze and predict which parts of a pathogen, allergen or cancer cell are targeted by immune responses. Identifying these specific molecular targets of immune responses, called epitopes, recognized by diseased individuals opens a path towards the development of diagnostics, vaccines and therapeutics for that particular disease. The tools the Peters lab develops aim to reduce the experimental effort required to identify these targets; computer-based predictions allow researchers to focus on the components most likely to be recognized rather than screening thousands of molecules.

The second research area of the lab is the identification of differences between immune cells in individuals with opposite disease outcomes. Powerful experimental tools have been developed to detect differences in how cells utilize the diverse parts of the genome. The Peters lab is using these tools to characterize how immune cells from diseased individuals differ from healthy individuals. These cells are isolated using disease-specific epitopes (or reagents based on them), so our epitope-identifying algorithms directly aid our disease-focused work. This research helps us understand how the disease develops and identifies potential targets in the genome for interventions to treat or prevent the disease.

Finally, the Peters lab is deeply involved in the development of community standards for knowledge representation to promote interoperability and re-use of data. The Peters and Sette lab maintain the Immune Epitope Database (www.iedb.org), which catalogs all published experiments on immune epitope recognition. This requires transforming free text information from journal publications into a structured format, and to make the information optimally useful, connecting it with information stored elsewhere. Doing this efficiently requires a community consensus on knowledge representation. Dr. Peters’ team is contributing to such consensus building and standardization efforts through active work on scientific community initiatives such as the Ontology of Biomedical Investigations (OBI, http://obi-ontology.org/).

Featured publications

Jun 25, 2019 Elife
Circulating T cell-monocyte complexes are markers of immune perturbations
Burel JG, Pomaznoy M, Lindestam Arlehamn CS, Weiskopf D, da Silva Antunes R, Jung Y, Babor M, Schulten V, Seumois G, Greenbaum JA, Premawansa S, Premawansa G, Wijewickrama A, Vidanagama D, Gunasena B, Tippalagama R, deSilva AD, Gilman RH, Saito M, Taplitz R, Ley K, Vijayanand P, Sette A, Peters B
Show more publications

Lab Members

JB
JB
AC
JD
AF
AF
HH
MK
DM
AM
JM
BP
KS
PS
LS
JS
RT

Research Projects

Peters
Allergic Diseases

Pediatric Milk Allergy: To study the frequency and phenotype of milk allergen-specific T cells in cohorts with different disease manifestations

READ MORE
Peters
Cancer

Immunotherapies for head and neck cancer: To develop new cancer therapies by studying how the immune system, by way of

READ MORE
Peters
Data Standards

HIPC Data Standards: A collaboration with various centers of the Human Immune Profiling Consortium (HIPC) to build upon the existing

READ MORE
Peters
Epigenetic and Transcriptomic Profile of Human Immune Cells

The lab aims to perform epigenetic and transcriptomic analyses of purified circulating immune cell types from healthy human subjects. NIH/NIAID

READ MORE
Vijayanand/Sette/Peters
Human Immune Profiling Consortium

The aim of this work, in collaboration with Bjoern Peters, Ph.D., and Pandurangan Vijayanand, M.D., Ph.D., is to characterize the

READ MORE
Peters
SARS-COV-2

COVIC-DB: To co-run the LJI-led CoVIC database in the effort to find ideal therapeutic combinations for the novel coronavirus, the

READ MORE
more research projects

From the lab

Show More