Klaus Ley Receives $2.3 Million to Study Fundamentals of Immune Cell Activation
LA JOLLA—Scientists at La Jolla Institute for Immunology (LJI) have received a new grant of more than $2.3 million from the National
T Cells
T cells are central to almost all immune responses. The CD4 subset is capable of directing B cell responses and
The Contribution of Central and/or Peripheral Tolerance in Celiac Disease
Celiac Disease (CD) is an autoimmune-like inflammatory disease induced by aberrant immune responses initiated by MHC class II restricted CD4
Mucosal CD4- CD8- T Cells
One large subgroup of specialized T cells is encompassed by the intraepithelial T cells which are located in the epithelium
Researchers track down metabolic enzyme that protects against inflammation
LA JOLLA, CA—Scrape your knee, and you’ll see some red puffiness appear around the injury. This is inflammation, and it
Role of Pre-TCR Signaling in Central Tolerance and Autoimmunity?
Autoimmunity is a self-destructive disease condition mediated mainly by pathogenic selfreactive αβ T cell receptor (TCR) expressing T lymphocytes. Self-tolerance
CD4+ Cytotoxic Lymphocytes
MHC class-II restricted CD4+ T cytotoxic cells (CD4 CTL) are among the best examples of extreme measures the immune system
T Cell Function
We are now trying to elucidate the regulatory functions displayed by the self-specific agonist selected T cells and their role
T Cells
One large subgroup of these specialized T cells is encompassed by the IEL which are located in the epithelium of
PKCq
PKC enzymes play critical roles in the differentiation and proliferation of many cell types, including T cells, and in the response to diverse stimuli.
Sharma Lab
Sonia Sharma,
Ph.D.
Associate Professor
Center for Autoimmunity and Inflammation, Center for Cancer Immunotherapy
Sonia Sharma, Ph.D., and her lab members lead unbiased, genome-scale approaches to unravel innate immunity, the body’s early immune response to microbial pathogens and neoplastic cells.
