A new window into autoimmune diseases
LJI scientists uncover coordinated immune cell activity as a driver of systemic lupus erythematosus
Learning from men. Learning from women.
Men and women have different immune systems. With a better understanding of sex-specific immune differences, scientists can more effectively fight infections, cancers, heart disease, and even pregnancy complications.
Myers Lab Laboratory for Immunochemical Circuits
Sam Myers,
Ph.D.
Assistant Professor
Laboratory for Immunochemical Circuits
Samuel Myers, Ph.D., studies the signaling circuits that drive the behavior of individual immune cells and ultimately orchestrate systemic immune responses.
Proteomics expert Sam Myers to join LJI faculty
Myers Lab to expand autoimmune disease research, cancer and more
Klaus Ley Receives $2.3 Million to Study Fundamentals of Immune Cell Activation
LA JOLLA—Scientists at La Jolla Institute for Immunology (LJI) have received a new grant of more than $2.3 million from the National
T Cells
T cells are central to almost all immune responses. The CD4 subset is capable of directing B cell responses and
The Contribution of Central and/or Peripheral Tolerance in Celiac Disease
Celiac Disease (CD) is an autoimmune-like inflammatory disease induced by aberrant immune responses initiated by MHC class II restricted CD4
Mucosal CD4- CD8- T Cells
One large subgroup of specialized T cells is encompassed by the intraepithelial T cells which are located in the epithelium
Researchers track down metabolic enzyme that protects against inflammation
LA JOLLA, CA—Scrape your knee, and you’ll see some red puffiness appear around the injury. This is inflammation, and it
Role of Pre-TCR Signaling in Central Tolerance and Autoimmunity?
Autoimmunity is a self-destructive disease condition mediated mainly by pathogenic selfreactive αβ T cell receptor (TCR) expressing T lymphocytes. Self-tolerance
CD4+ Cytotoxic Lymphocytes
MHC class-II restricted CD4+ T cytotoxic cells (CD4 CTL) are among the best examples of extreme measures the immune system
T Cell Function
We are now trying to elucidate the regulatory functions displayed by the self-specific agonist selected T cells and their role