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Croft
T Cells

T cells are central to almost all immune responses. The CD4 subset is capable of directing B cell responses and

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Cheroutre
The Contribution of Central and/or Peripheral Tolerance in Celiac Disease

Celiac Disease (CD) is an autoimmune-like inflammatory disease induced by aberrant immune responses initiated by MHC class II restricted CD4

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Cheroutre
Mucosal CD4- CD8- T Cells

One large subgroup of specialized T cells is encompassed by the intraepithelial T cells which are located in the epithelium

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Cheroutre
Role of Pre-TCR Signaling in Central Tolerance and Autoimmunity?

Autoimmunity is a self-destructive disease condition mediated mainly by pathogenic selfreactive αβ T cell receptor (TCR) expressing T lymphocytes. Self-tolerance

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Cheroutre
CD4+ Cytotoxic Lymphocytes

MHC class-II restricted CD4+ T cytotoxic cells (CD4 CTL) are among the best examples of extreme measures the immune system

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Cheroutre
T Cell Function

We are now trying to elucidate the regulatory functions displayed by the self-specific agonist selected T cells and their role

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Cheroutre
T Cells

One large subgroup of these specialized T cells is encompassed by the IEL which are located in the epithelium of

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Altman
PKCq

PKC enzymes play critical roles in the differentiation and proliferation of many cell types, including T cells, and in the response to diverse stimuli.

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Sharma Lab
Sonia Sharma, Ph.D.
Associate Professor
Center for Autoimmunity and Inflammation, Center for Cancer Immunotherapy

Sonia Sharma, Ph.D., and her lab members lead unbiased, genome-scale approaches to unravel innate immunity, the body’s early immune response to microbial pathogens and neoplastic cells.

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Rao Lab
Anjana Rao, Ph.D.
Professor
Center for Autoimmunity and Inflammation, Center for Cancer Immunotherapy

Anjana Rao, Ph.D., focuses on understanding how signaling pathways control gene expression, using T cells and other cells of the immune system as models.

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