The longer the bootcamp, the better the antibodies

Sep 21, 2022 Research News

The longer the bootcamp, the better the antibodies

LA JOLLA, CA—Researchers at La Jolla Institute for Immunology (LJI) have discovered how the immune system can transform into an

May 26, 2022 Research News

LJI scientists publish first head-to-head comparison of four COVID-19 vaccines

Correction: A previous version of this article incorrectly stated that “Participants given the Janssen/J&J vaccine had the highest percentage of

Jan 1, 2021 Semin Immunol.

HIV vaccinology: 2021 update.

Lee JH, Crotty S.

Feb 18, 2021 Cell.

Adaptive immunity to SARS-CoV-2 and COVID-19.

Sette A, Crotty S.

Feb 16, 2021 Cell Rep Med.

Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases.

Tarke A, Sidney J, Kidd CK, Dan JM, Ramirez SI, Yu ED, Mateus J, da Silva Antunes R, Moore E, Rubiro P, Methot N, Phillips E, Mallal S, Frazier A, Rawlings SA, Greenbaum JA, Peters B, Smith DM, Crotty S, Weiskopf D, Grifoni A, Sette A.

Feb 5, 2021 Science.

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection.

Dan JM, Mateus J, Kato Y, Hastie KM, Yu ED, Faliti CE, Grifoni A, Ramirez SI, Haupt S, Frazier A, Nakao C, Rayaprolu V, Rawlings SA, Peters B, Krammer F, Simon V, Saphire EO, Smith DM, Weiskopf D, Sette A, Crotty S.

Feb 1, 2021 J Exp Med.

Modulating the quantity of HIV Env-specific CD4 T cell help promotes rare B cell responses in germinal centers.

Lee JH, Hu JK, Georgeson E, Nakao C, Groschel B, Dileepan T, Jenkins MK, Seumois G, Vijayanand P, Schief WR, Crotty S.

Jan 15, 2021 EMBO J.

Multiplexed CRISPR/CAS9-mediated engineering of pre-clinical mouse models bearing native human B cell receptors.

Wang X, Ray R, Kratochvil S, Melzi E, Lin YC, Giguere S, Xu L, Warner J, Cheon D, Liguori A, Groschel B, Phelps N, Adachi Y, Tingle R, Wu L, Crotty S, Kirsch KH, Nair U, Schief WR, Batista FD.

Apr 1, 2021 Trends Immunol.

Bcl6-mediated transcriptional regulation of follicular helper T cells (TFH).

Choi J, Crotty S.

Aug 2, 2021 J Exp Med.

Bromodomain protein BRD4 directs and sustains CD8 T cell differentiation during infection.

Milner JJ, Toma C, Quon S, Omilusik K, Scharping NE, Dey A, Reina-Campos M, Nguyen H, Getzler AJ, Diao H, Yu B, Delpoux A, Yoshida TM, Li D, Qi J, Vincek A, Hedrick SM, Egawa T, Zhou M-M, Crotty S, Ozato K, Pipkin ME, Goldrath AW.

Jul 20, 2021 Cell Rep Med.

Impact of SARS-CoV-2 variants on the total CD4+ and CD8+ T cell reactivity in infected or vaccinated individuals.

Tarke A, Sidney J, Methot N, Yu ED, Zhang Y, Dan JM, Goodwin B, Rubiro P, Sutherland A, Wang E, Frazier A, Ramirez SI, Rawlings SA, Smith DM, da Silva Antunes R, Peters B, Scheuermann RH, Weiskopf D, Crotty S, Grifoni A, Sette A.

Jul 14, 2021 Cell Host Microbe.

SARS-CoV-2 human T cell epitopes: adaptive immune response against COVID-19.

Grifoni A, Sidney J, Vita R, Peters B, Crotty S, Weiskopf D, Sette A.