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Oct 11, 2021 Research News

Lungs of COVID-19 survivors teem with virus-fighting ‘memory’ cells

Even elderly survivors show a strong, persistent immune memory

Apr 2, 2021 J Infect Dis

Differential T cell reactivity to endemic coronaviruses and SARS-CoV-2 in community and health care workers

Da Silva Antunes R, Pallikkuth S, Williams E, Esther DY, Mateus J, Quiambao L, Wang E, Rawlings SA, Stadlbauer D, Jiang K, Amanat F, Arnold D, Andrews D, Fuego I, Dan JM, Grifoni A, Weiskopf D, Krammer F, Crotty S, Hoffer ME, Pahwa SG, Sette A

Jan 15, 2021 EMBO J

Multiplexed CRISPR/CAS9-mediated engineering of pre-clinical mouse models bearing native human B cell receptors

Wang X, Ray R, Kratochvil S, Melzi E, Lin YC, Giguere S, Xu L, Warner J, Cheon D, Liguori A, Groschel B, Phelps N, Adachi Y, Tingle R, Wu L, Crotty S, Kirsch KH, Nair U, Schief WR, Batista FD

Feb 1, 2021 J Exp Med

Modulating the quantity of HIV Env-specific CD4 T cell help promotes rare B cell responses in germinal centers

Lee JH, Hu JK, Georgeson E, Nakao C, Groschel B, Dileepan T, Jenkins MK, Seumois G, Vijayanand P, Schief WR, Crotty S

Apr 1, 2021 Trends Immunol

Bcl6-mediated transcriptional regulation of follicular helper T cells (TFH)

Choi J, Crotty S

Jul 2, 2021 Cell Rep Med

Impact of SARS-CoV-2 variants on the total CD4+ and CD8+ T cell reactivity in infected or vaccinated individuals

Tarke A, Sidney J, Methot N, Ye ED, Zhang Y, Dan JM, Goodwin B, Rubiro P, Sutherland A, Wang E, Frazier A, Ramirez SI, Rawlings SA, Smith DM, da Silva Antunes R, Peters B, Scheuermann RH, Weiskopf D, Crotty S, Grifoni A, Sette A

May 14, 2021 Clin Infect Dis

Increased peripheral blood neutropil activation phenotypes and NETois in critically ill COVID-19 patients: a case series and review of the literature

Masso-Silva JA, Moshensky A, Lam MTY, Odish M, Patel A, Xu L, Hansen E, Trescott S, Nguyen C, Kim R, Perofsky K, Perera S, Ma L, Pham J, Rolfsen M, Olay J, Shin J, Dan JM, Abbott R, Ramirez S, Alexander TH, Lin GY, Fuentes AL, Advani I, Gunge D, Pretorius V, Malhotra A, Sun X, Duran J, Hepokoski M, Crotty S, Coufal NG, Meier A, Crotty Alexander LE

May 21, 2021 Cell Host Microbe

SARS-CoV-2 huan T cell epitopes: adaptive immune response against COVID-19

Grifoni A, Sidney J, Vita R, Peters B, Crotty S, Weiskopf D, Sette A

Jun 11, 2021 EBioMedicine

AI-guided discovery of the invariant host response to viral pandemics

Sahoo D, Katkar GD, Khandelwal S, Behroozikhah M, Claire A, Castillo V, Tindle C, Fuller M, Taheri S, Rogers TF, Beutler N, Ramirez SI, Rawlings SA, Pretorius V, Smith DM, Burton DR, Crotty Alexander LE, Duran J, Crotty S, Dan JM, Das S, Ghosh P

Aug 2, 2021 J Exp Med

Bromodomain protein BRD4 directs and sustains CD8 T cell differentiation during infection

Milner JJ, Toma C, Quon S, Omilusik K, Scharping NE, Dey A, Reina-Campos M, Nguyen H, Getzler AJ, Diao H, Yu B, Delpoux A, Yoshida TM, Li D, Qi J, Vincek A, Hedrick SM, Egawa T, Zhou M-M, Crotty S, Ozato K, Pipkin ME, Goldrath AW

May 31, 2021 Front Physiol

Chronic E-Cigarette Aerosol Inhalation Alters the Immune State of the Lungs and Increases ACE2 Expression, Raising Concern for Altered Response and Susceptibility to SARS-CoV-2

Masso-Silva JA, Moshensky A, Shin J, Olay J, Nilaad S, Advani I, Bojanowski CM, Crotty S, Li WT, Ongkeko WM, Singla S, Alexander LEC

Sep 14, 2021 Science

Low-dose mRNA-1273 COVID-19 vaccine generates durable memory enhanced by cross-reactive T cells

Mateus J, Dan JM, Zhang Z, Rydyznski Moderbacher C, Lammers M, Goodwin B, Sette A, Crotty S, Weiskopf D.