My laboratory is focused on understanding T cell immune responses to Mycobacterium tuberculosis and other infections, as well as self-antigens in the context of neurodegenerative diseases.
Specifically, the identification of T cell epitopes and characterization of T cell subsets resulting from the immune response to tuberculosis. Our work has illustrated that the T cell immune response is broader than previously understood. This led to the development of a peptide megapool (MTB300) that can be used to characterize TB-specific T cell immune responses, which has been used by multiple collaborators to characterize TB-specific or vaccine-induced responses.
We are also interested in defining the role of non-tuberculous mycobacteria in the immune response against TB and vaccinations.
Finally, we study T cell responses directed against self-proteins with implications for neurodegenerative diseases such as Parkinson’s, Alzheimer’s, and ALS. This work has identified α-synuclein as a target for T cell immune responses in Parkinson’s disease (PD) which provided evidence that autoimmunity plays a role in PD.
Our goal is to understand these immune responses better to help develop better diagnostics and more effective therapies.
The aim of this work funded by Aligning Science Across Parkinson’s (ASAP), in collaboration with Dr. Alessandro Sette, is to
The aim of this work, in collaboration with Dr. Bjoern Peters, is to identify and characterize T cell epitopes from
The lab page is online! 🥳 lji.org/labs/lindestam…
Take a look at our collection on Exploring Immune Variability in Susceptibility to Tuberculosis Infection in Humans Thank you all contributors and co-editors Julie, @SeshadriChetan and @Sutherland_TB @ljiresearch frontiersin.org/articles/10.33…
Congratulations! They are lucky to have you! All the best
Dreaming of a white Christmas ❄️🥰Happy holidays!
RT @ljiresearch: Profiling #Tcell responses to human #CMV reveals novel immunogenic open reading frames doi.org/10.1128/JVI.00… This LJI…
RT @biorxiv_immuno: CD4 T cells are rapidly depleted from tuberculosis granulomas following acute SIV co-infection biorxiv.org/cgi/content/sh……
Really great work by @TaylorForeman19 and @danielleobarber twitter.com/TaylorForeman1…
You'll be great! All the best!
RT @ljiresearch: More new #tuberculosis vaccine findings: Dr. Cecilia Arlehamn Lindestam and Statens Serum Institut scientists show how we…
Congratulations Dr. Mpande! Well done!
RT @ljiresearch: Tuberculosis kills 1.5M people each year. Now LJI scientists have uncovered exactly how the immune system responds to the…
Check out our new publication where we characterize the BCG-induced immune signature and find an important role (again) for Th1* cells sciencedirect.com/science/articl… @ljiresearch @SetteLab @BjoernPeters2
Awards & Honors
- 2020 Tullie and Rickey Families SPARK Awards Winner
- Bill and Melinda Gates Foundation Collaboration for TB Vaccine Discovery – Early Career Scientist Award Fall 2016