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LJI Research Assistant Professor Cecilia Lindestam Arlehamn, Ph.D.
Cecilia Lindestam Arlehamn, Ph.D.
Assistant Professor
"I’m driven by the novel challenges posed by the ever-changing nature of the immune system to be creative, push boundaries and discover new factors that can aid in fighting diseases."

Overview

My laboratory is focused on understanding T cell immune responses to Mycobacterium tuberculosis and other infections, as well as self-antigens in the context of neurodegenerative diseases.

Specifically, the identification of T cell epitopes and characterization of T cell subsets resulting from the immune response to tuberculosis. Our work has illustrated that the T cell immune response is broader than previously understood. This led to the development of a peptide megapool (MTB300) that can be used to characterize TB-specific T cell immune responses, which has been used by multiple collaborators to characterize TB-specific or vaccine-induced responses.

We are also interested in defining the role of non-tuberculous mycobacteria in the immune response against TB and vaccinations.

Finally, we study T cell responses directed against self-proteins with implications for neurodegenerative diseases such as Parkinson’s, Alzheimer’s, and ALS. This work has identified α-synuclein as a target for T cell immune responses in Parkinson’s disease (PD) which provided evidence that autoimmunity plays a role in PD.

Our goal is to understand these immune responses better to help develop better diagnostics and more effective therapies.

Featured publications

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Lab Members

JM
KS

Research Projects

Lindestam Arlehamn
Neurodegenerative Diseases

The aim of this work funded by Aligning Science Across Parkinson’s (ASAP), in collaboration with Dr. Alessandro Sette, is to

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Lindestam Arlehamn
Tuberculosis

The aim of this work, in collaboration with Dr. Bjoern Peters, is to identify and characterize T cell epitopes from

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From the lab

Dec 13, 2021 Research News
Once upon a BCG vaccine

  LA JOLLA—A long, long time ago, the BCG vaccine was approved for use against tuberculosis (TB), and it’s still

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Awards & Honors

  • 2020 Tullie and Rickey Families SPARK Awards Winner
  • Bill and Melinda Gates Foundation Collaboration for TB Vaccine Discovery – Early Career Scientist Award Fall 2016