The aim of this work, in collaboration with Dr. Bjoern Peters, is to identify and characterize T cell epitopes from Mycobacterium tuberculosis in vaccination and active infection (NIH/NIAID, 75N93019C00067). We are also interested in defining human immune signatures of different stages of Mtb infection.
In collaboration with Dr. Tom Hawn at the University of Washington, we are characterizing immune responses against the non-tuberculous mycobacterium M. avium.
Selected publications:
Woodworth et al., A Mycobacterium tuberculosis-specific subunit vaccine that provides synergistic immunity upon co-administration with Bacillus Calmette-Guérin, Nat Commun, 2021
https://pubmed.ncbi.nlm.nih.gov/34795205/
Burel et al., Distinct blood transcriptomic signature of treatment in latent tuberculosis infected individuals at risk of developing active disease, Tuberculosis (Edinb), 2021
https://pubmed.ncbi.nlm.nih.gov/34555657/
Tippalagama et al., HLA-DR Marks Recently Divided Antigen-Specific Effector CD4 T Cells in Active Tuberculosis Patients, J Immunol, 2021
https://pubmed.ncbi.nlm.nih.gov/34193602/
Morgan et al., Classical CD4 T cells as the cornerstone of antimycobacterial immunity, Immunol Rev, 2021
https://pubmed.ncbi.nlm.nih.gov/33751597/
Kuan et al., Is mapping the BCG vaccine-induced immune responses the key to improving the efficacy against tuberculosis?, J Intern Med, 2020
https://pubmed.ncbi.nlm.nih.gov/33210407/
Pomaznoy et al., Quantitative and Qualitative Perturbations of CD8+ MAITs in Healthy Mycobacterium tuberculosis-Infected Individuals, ImmunoHorizons, 2020
https://pubmed.ncbi.nlm.nih.gov/32499216/
Shah et al., Nontuberculous Mycobacteria and Heterologous Immunity to Tuberculosis, J Infect Dis, 2019
https://pubmed.ncbi.nlm.nih.gov/31165861/
Scriba et al., Differential Recognition of Mycobacterium tuberculosis-Specific Epitopes as a Function of Tuberculosis Disease History, Am J Respir Crit Care Med, 2017
https://pubmed.ncbi.nlm.nih.gov/28759253/
Lindestam Arlehamn et al., A Quantitative Analysis of Complexity of Human Pathogen-Specific CD4 T Cell Responses in Healthy M. tuberculosis Infected South Africans, PLoS Pathog, 2016
https://pubmed.ncbi.nlm.nih.gov/27409590/
Carpenter et al., A side-by-side comparison of T cell reactivity to fifty-nine Mycobacterium tuberculosis antigens in diverse populations from five continents, Tuberculosis (Edinb), 2015
https://pubmed.ncbi.nlm.nih.gov/26277695/
Lindestam Arlehamn et al., Immunological consequences of intragenus conservation of Mycobacterium tuberculosis T-cell epitopes, Proc Natl Acad Sci U S A, 2015
https://pubmed.ncbi.nlm.nih.gov/25548174/
Lindestam Arlehamn et al., Transcriptional profile of tuberculosis antigen-specific T cells reveals novel multifunctional features, J Immunol, 2014
https://pubmed.ncbi.nlm.nih.gov/25092889/
Lindestam Arlehamn et al., Memory T cells in latent Mycobacterium tuberculosis infection are directed against three antigenic islands and largely contained in a CXCR3+CCR6+ Th1 subset, PLoS Pathog, 2013
https://pubmed.ncbi.nlm.nih.gov/23358848/