T cell responses to Mycobacterium tuberculosis infection and vaccination: Following completion of a massive epitope discovery effort (also supported by an NIH contract), current work on TB includes identifying T cell signatures and immune responses elicited by non-tuberculous mycobacteria, which may influence TB-specific immune responses, and identifying immune mechanisms that can distinguish individuals with high risk of progression to active infection.
Selected References
Shah JA, Lindestam Arlehamn CS, Horne DJ, Sette A, Hawn TR. Nontuberculous Mycobacteria and Heterologous Immunity to Tuberculosis. J Infect Dis. 2019 Aug 30;220(7):1091-1098. doi: 10.1093/infdis/jiz285. PubMed PMID: 31165861; PubMed Central PMCID: PMC6736075.
Burel JG, Lindestam Arlehamn CS, Khan N, Seumois G, Greenbaum JA, Taplitz R, Gilman RH, Saito M, Vijayanand P, Sette A, Peters B. Transcriptomic Analysis of CD4(+) T Cells Reveals Novel Immune Signatures of Latent Tuberculosis. J Immunol. 2018 May 1;200(9):3283-3290. doi: 10.4049/jimmunol.1800118. Epub 2018 Mar 30. PubMed PMID: 29602771; PubMed Central PMCID: PMC5991485.
Scriba TJ, Carpenter C, Pro SC, Sidney J, Musvosvi M, Rozot V, Seumois G, Rosales SL, Vijayanand P, Goletti D, Makgotlho E, Hanekom W, Hatherill M, Peters B, Sette A, Arlehamn CSL. Differential Recognition of Mycobacterium tuberculosis-Specific Epitopes as a Function of Tuberculosis Disease History. Am J Respir Crit Care Med. 2017 Sep 15;196(6):772-781. doi: 10.1164/rccm.201706-1208OC. PubMed PMID: 28759253; PubMed Central PMCID: PMC5620682.
Lindestam Arlehamn CS, McKinney DM, Carpenter C, Paul S, Rozot V, Makgotlho E, Gregg Y, van Rooyen M, Ernst JD, Hatherill M, Hanekom WA, Peters B, Scriba TJ, Sette A. A Quantitative Analysis of Complexity of Human Pathogen-Specific CD4 T Cell Responses in Healthy M. tuberculosis Infected South Africans. PLoS Pathog. 2016 Jul 13;12(7):e1005760. doi: 10.1371/journal.ppat.1005760. eCollection 2016 Jul. PubMed PMID: 27409590; PubMed Central PMCID: PMC4943605.
Lindestam Arlehamn CS, Paul S, Mele F, Huang C, Greenbaum JA, Vita R, Sidney J, Peters B, Sallusto F, Sette A. Immunological consequences of intragenus conservation of Mycobacterium tuberculosis T-cell epitopes. Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):E147-55. doi: 10.1073/pnas.1416537112. Epub 2014 Dec 29. PubMed PMID: 25548174; PubMed Central PMCID: PMC4299226.
Paul S, Lindestam Arlehamn CS, Scriba TJ, Dillon MB, Oseroff C, Hinz D, McKinney DM, Carrasco Pro S, Sidney J, Peters B, Sette A. Development and validation of a broad scheme for prediction of HLA class II restricted T cell epitopes. J Immunol Methods. 2015 Jul;422:28-34. doi: 10.1016/j.jim.2015.03.022. Epub 2015 Apr 7. PubMed PMID: 25862607; PubMed Central PMCID: PMC4458426.
Lindestam Arlehamn CS, Gerasimova A, Mele F, Henderson R, Swann J, Greenbaum JA, Kim Y, Sidney J, James EA, Taplitz R, McKinney DM, Kwok WW, Grey H, Sallusto F, Peters B, Sette A. Memory T cells in latent Mycobacterium tuberculosis infection are directed against three antigenic islands and largely contained in a CXCR3+CCR6+ Th1 subset. PLoS Pathog. 2013 Jan;9(1):e1003130.