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Jul 25, 2019 Sci Rep

Septins organize endoplasmic reticulum-plasma membrane junctions for STIM1-ORAI1 calcium signalling

Katz ZB, Zhang C, Quintana A, Lilemeier BF, Hogan PG

Sep 30, 2019 Nat Rev Immunol

Defining ‘T cell exhaustion’

Blank CU, Haining WN, Held W, Hogan PG, Kallies A, Lugil E, Lynn RC, Philip M, Rao A, Restifo NP, Schietinger A, Schumacher TN, Schwartzberg PL, Sharpe AH, Speiser DE, Wherry EJ, Youngblood BA, Zehn D

Jan 1, 2010 Nat Struct Mol Biol

STIM1 gates the store-operated calcium channel ORAI1 in vitro

Zhou Y, Meraner P, Kwon HT, Machnes D, Oh-hora M, Zimmer J, Huang Y, Rao A, Hogan PG

Mar 16, 2010 Proc Natl Acad Sci USA

Pore architecture of the ORAI1 store-operated calcium channel

Zhou Y, Ranganathan S, Oh-hora M, Rao A, Hogan PG

Mar 1, 2010 Annu Rev Immunol

Molecular basis of calcium signalling in lymphocytes: STIM and ORAI

Hogan PG, Lewis RL, Rao A

May 14, 2019 Proc Natl Acad Sci U S A

Targeting the NFAT:AP-1 transcriptional complex on DNA with a small-molecule inhibitor

Mognol GP, González-Avalos E, Ghosh S, Spreafico R, Gudlur A, Rao A, Damoiseaux R, Hogan PG

Jun 18, 2019 Proc Natl Acad Sci U S A

TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion

Seo H, Chen J, González-Avalos E, Samaniego-Castruita D, Das A, Wang YH, López-Moyado IF, Georges RO, Zhang W, Onodera A, Wu CJ, Lu LF, Hogan PG, Bhandoola A, Rao A

Jun 22, 2019 J Physiol

STIM calcium sensing and conformational change

Gudlur A, Zeraik AE, Hirve N, Hogan PG

Apr 22, 2019 Research News

To respond or tolerate? LJI researchers selectively block immune activation program orchestrated by the nuclear factor NFAT

LA JOLLA, CA—The immune system occasionally makes mistakes that require correction. For example, in autoimmunity, T-cells lose “immune tolerance” of

Dec 6, 2018 Elife

Hogan

Septins organize endoplasmic reticulum-plasma membrane junctions for STIM1-ORAI1 calcium signalling

Defining ‘T cell exhaustion’

STIM1 gates the store-operated calcium channel ORAI1 in vitro

Pore architecture of the ORAI1 store-operated calcium channel

Molecular basis of calcium signalling in lymphocytes: STIM and ORAI

Targeting the NFAT:AP-1 transcriptional complex on DNA with a small-molecule inhibitor

TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion

STIM calcium sensing and conformational change

To respond or tolerate? LJI researchers selectively block immune activation program orchestrated by the nuclear factor NFAT

A secretory pathway kinase regulates sarcoplasmic reticulum Ca2+ homeostasis and protects against heart failure

Coiled-coil formation conveys a STIM1 signal from ER lumen to cytoplasm

Calcium sensing by the STIM1 ER-luminal domain