Preparing T cells for the long haul
New LJI research could keep cancer-fighting T cells from burning out before the job is done
Defining ‘T cell exhaustion’
STIM1 gates the store-operated calcium channel ORAI1 in vitro
Pore architecture of the ORAI1 store-operated calcium channel
Molecular basis of calcium signalling in lymphocytes: STIM and ORAI
Targeting the NFAT:AP-1 transcriptional complex on DNA with a small-molecule inhibitor
TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion
STIM calcium sensing and conformational change
To respond or tolerate? LJI researchers selectively block immune activation program orchestrated by the nuclear factor NFAT
LA JOLLA, CA—The immune system occasionally makes mistakes that require correction. For example, in autoimmunity, T-cells lose “immune tolerance” of