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Catherine Hedrick, Ph.D.
Professor
Center for Autoimmunity and Inflammation, Center for Cancer Immunotherapy
"My interest in science began when I was a child, as my mother suffered from complications of Type 1 diabetes, and so when I was little, I always wanted to study it. Later, I became interested in cardiovascular disease, which is also a complication of diabetes, as a global health concern. I hope my work at the la Jolla Institute will bring new opportunities to find therapies to reduce or prevent atherosclerosis development."

Overview

There are 3 main areas of research in the lab. A primary goal in the laboratory is to study and target monocytes to aid in the prevention of cancer. Some monocytes are pro-tumoral, and other monocyte subsets are anti-tumoral, as we have shown that nonclassical monocytes prevent tumor metastasis. We want to understand more about how these monocyte subsets impact cancer initiation and progression. The second research goal is to study neutrophil heterogeneity in cancer and cardiovascular disease. We use high dimensional methods including CyTOF mass cytometry and single cell RNA-Sequencing to identify new myeloid cell and T cell subsets that may be important in cardiovascular disease and cancer. We wish to determine how these immune cells phenotypically and functionally change, and how they interact in the microenvironments of the atherosclerotic plaque and the tumor. We can compare and contrast these immune cell interactions in these two diseases to identify effective new combination immunotherapies.

Featured publications

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Lab Members

DA
DB
NG
CH
CH
MM
ET
RW
DY
YZ

Research Projects

Hedrick
CD8 T Cell Functions in Atherosclerosis

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Hedrick
Epigenetic Regulation of Neutrophil and Monocyte Development in Disease

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Hedrick
Immunoprofiling of Human Immune Cells in Cardiovascular Disease and Cancer

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Hedrick
Regulation of Treg Function in Cardiovascular Disease

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From the lab

Sep 21, 2018 Immune Matters
Immunoprofiling

The composition of an immune system varies not just from person to person, but over time—shifting as our health changes,

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Awards & Honors

  • Chair, GRC on Atherosclerosis, 2019
  • Mentor of Women Award, ATVB Council, American Heart Association, 2015
  • Jeffrey M. Hoeg Arteriosclerosis Thrombosis and Vascular Biology Award for Basic Science and Clinical Research, American Heart Association, 2014
  • ATVB Vascular Biology Special Recognition Award, American Heart Association, 2013
  • Co-Chair of 2012 Keystone Conference on Inflammation and Atherosclerosis
  • Associate Editor, Arteriosclerosis Thrombosis and Vascular Biology, 2010
  • Harrison Distinguished Chair in Molecular Physiology, University of Virginia, 2009
  • Mary Jane Kugel Award, JDRF, 2005, 2008
  • Recipient, Atorvastatin National Research Award for Cardiovascular Research, Pfizer, 2000
  • Laverna Titus Young Investigator Award for Basic Science, American Heart Association, Los Angeles Affiliate, 1993, 1995
  • Finalist, Young Investigator Award, International Atherosclerosis Society, 1994