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Apr 1, 2021 Nat Immunol

The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING-IFN-β pathway.

Takahashi M, Lio CJ, Campeau A, Steger M, Ay F, Mann M, Gonzalez DJ, Jain M, Sharma S.

Mar 15, 2021 J Immunol

Functional analysis of immue signature genes in Th1* memory cells links ISOC1 and pyrimidine metabolism to IFN-g and IL-17 production

Kushnareva, Y., Mathews, I.T., Andreyev, A.Y., Altay, G., Lindestam Arlehamn, C.S., Pandurangan, V., Nilsson, R., Jain, M., Sette, A., Peters, B., and Sharma, S

Jul 6, 2021 Genome Biol

Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease

Chu X, Jaeger M, Beumer J, Bakker OB, Aguirre-Gamboa R, Oosting M, Smeekens SP, Moorlag S, Mourits VP, Koeken V, de Bree C, Jansen T, Mathews IT, Dao K, Najhawan M, Watrous JD, Joosten I, Sharma S, Koenen H, Withoff S, Jonkers IH, Netea-Maier RT, Xavier RJ, Franke L, Xu CJ, Joosten LAB, Sanna S, Jain M, Kumar V, Clevers H, Wijmenga C, Netea MG, Li Y

May 27, 2021 J Mass Spectrom

Nontargeted mass spectrometry of dried blood spots for interrogation of the human circulating metabolome

Ward C, Nallamshetty S, Watrous JD, Acres E, Long T, Mathews IT, Sharma S, Cheng S, Imam F, Jain M

Feb 12, 2021 BMJ Open

Seroprevalence of antibodies to SARS-CoV-2 in healthcare workers: a cross-sectional study

Ebinger JE, Botwin GJ, Albert CM, Alotaibi M, Arditi M, Berg AH, Binek A, Botting P, Fert-Bober J, Figueiredo JC, Grein JD, Hasan W, Henglin M, Hussain SK, Jain M, Joung S, Karin M, Kim EH, Li D, Liu Y, Luong E, McGovern DPB, Merchant A, Merin N, Miles PB, Minissian M, Nguyen TT, Raedschelders K, Rashid MA, Riera CE, Riggs RV, Sharma S, Sternbach S, Sun N, Tourtellotte WG, Van Eyk JE, Sobhani K, Braun JG, Cheng S

Jul 6, 2021 Sci Rep

Genome-wide CRISPR/Cas9 screening in human iPS derived cardiomyocytes uncovers novel mediators of doxorubicin cardiotoxicity

Sapp V, Aguirre A, Mainkar G, Ding J, Adler E, Liao R, Sharma S, Jain M

Apr 23, 2021 Immune Matters

Learning from men. Learning from women.

Men and women have different immune systems. With a better understanding of sex-specific immune differences, scientists can more effectively fight infections, cancers, heart disease, and even pregnancy complications.

Mar 25, 2021 Research News

A clue to how some fast-growing tumors hide in plain sight

New LJI research could guide the development of more effective cancer immunotherapies

Nov 20, 2020 In the News

How to shift into COVID-19 research

Scientists who aren’t virologists or vaccinologists can still make crucial contributions to the global effort to battle SARS-CoV-2.

Jul 22, 2020 Sci Adv.

Cellular sensing of extracellular purine nucleosides triggers an innate IFN-β response.

Dhanwani R, Takahashi M, Mathews IT, Lenzi C, Romanov A, Watrous JD, Pieters B, Hedrick CC, Benedict CA, Linden J, Nilsson R, Jain M, Sharma S.

Jan 23, 2020 Gastroenterology

Identification of Lineage-Specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution

Liu X, Xu J, Rosenthal S, Zhang LJ, McCubbin R, Meshgin N, Shang L, Koyama Y, Ma HY, Sharma S, Heinz S, Glass CK, Benner C, Brenner DA, Kisseleva T

Sharma

Molecular Mechanisms Underlying Novel Interferonopathies

In addition to their protective role against microbial pathogens and neoplastic cells, high levels of circulating type I Interferon are