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Molecular Mechanisms Underlying Novel Interferonopathies

In addition to their protective role against microbial pathogens and neoplastic cells, high levels of circulating type I Interferon are

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Targeting Tumor Endothelium for Cancer Surveillance and Immunotherapy

Preliminary data from our lab shows that vascular endothelial cells (vECs) mount remarkably potent innate responses to cell-free DNA, which

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New Molecular Players in the cGAS-STING Pathway of Anti-Viral and Anti-Tumor Defense

Cell-free, immuno-stimulatory DNA is recognized in the cytoplasm of cells as a universal danger signal by the innate immune system.

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